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FLASH GENE
Symbol RGN contributors: mct - updated : 13-11-2024
HGNC name regucalcin (senescence marker protein-30)
HGNC id 9989
Location Xp11.3      Physical location : 46.937.774 - 46.952.712
Synonym name
  • regucalcin
  • gluconolactonase
  • senescence marker protein 30
    • Synonym symbol(s) SMP30, SEN3, RC, CTD-2522E6.2, GNL
    EC.number 3.1.1.17
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 14.87 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1635 33.3 299 - 2023 37468792
  • having different 5' UTR
  • encoding the same protein
    • 8 splicing 2168 33.3 299 - 2023 37468792
  • having different 5' UTR
  • encoding the same protein.
    • 7 - 1952 - 227 - 2023 37468792
    8 - 2119 - 246 - 2023 37468792
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart     Homo sapiens
    Digestiveliver   predominantly Homo sapiens
    Reproductivefemale systembreast    Homo sapiens
     male systemprostate    Homo sapiens
     male systemtestis    Homo sapiens
    Urinarykidney   predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    ReproductiveLeydig cell Homo sapiens
    ReproductiveSertoli cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus regucalcin
    ortholog to murine Rgn
    homolog to Drosophila regucalcin
    homolog to C.elegans C08F11.5
    intraspecies homolog to senescence marker protein 30
    Homologene
    FAMILY
  • SMP-30/CGR1 family
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in calcium homeostasis
  • playing a role in aging and in the regulation of the enzymatic activity in the liver
  • has protective effects against age-associated oxidative stress in brain and lungs
  • cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical warfare nerve agents
  • glucolactonase, which is a key enzyme for l-ascorbic acid (vitamin C) biosynthesis
  • has a suppressive effect on calcium signaling from the cytoplasm to the nucleus in the proliferative cells
  • plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function
  • calcium (Ca(2)(+))-binding protein which regulates intracellular Ca(2)(+) homeostasis by modulating the activity of enzymes regulating Ca(2)(+) concentration and enhancing Ca(2)(+)-pumping activity
  • may have a role in male reproductive function, particularly in the control of spermatogenesis
  • plays a role in Ca(2+) homeostasis by modulating a number of Ca(2+)-dependent proteins
  • also plays a cyto-protective role and its decrease is linked to age-related diseases and cell death
  • having a cardio-protective role with anti-oxidative and anti-aging effects
  • exogenous RGN may play a pivotal role in the regulation of bone homeostasis as a suppressor in osteoblastogenesis and an enhancer in osteoclastogenesis, suggesting its role as a cytokine
  • play a multifunctional role in cell regulation, such as maintainance of intracellular Ca2+ homeostasis and suppression of signal transduction, protein synthesis, nuclear function, cell proliferation and apoptosis in various types of cells and tissues
  • RGN may be a key molecule in heart muscle cell regulation through Ca2+ signaling, and may also play a pathophysiological role in heart failure
  • protective role of RGN in the carcinogenesis of mammary gland
  • role of RGN suppressing cell proliferation associated with the regulation of expression of oncogenes and tumor suppressor genes
  • acts as a Ca2+ regulatory protein and controls various cellular functions in liver and other organs
  • has multiple functions as an inhibitor of various cellular signaling pathways that regulate cell activity
  • plays an important role in the development of several cancers by controlling cell growth
  • regucalcin may act as a potential suppressor of various types of human cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text calcium
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • prevented cardiac hypertrophy and diastolic dysfunction by AGT
  • interaction between UPK1A and RGN or PSMB1 could be required for spermatogenesis
    • cell & other
    REGULATION
    repressed by aging (age-associated down-regulation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may contribute to the worsening of glucose tolerance that occurs in normal aging
    constitutional     --low  
    in nonalcoholic fatty liver disease
    tumoral     --low  
    in breast and prostate cancer cases and the regulation of its expression by sex steroid hormones suggest that it may be associated with development and progression of these tumors (
    constitutional     --over  
  • cardiac-specific overexpression of RGN inhibited AGT -induced cardiac adverse remodeling
    • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • reliable biomarker in various disorders of liver, kidney, brain and ocular
  • utility of RGN signaling as biomarkers for predicting recurrence of prostate carcinoma
    • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    therapeutic target to prevent cardiac hypertrophy and remodeling due to hypertension
    cancerreproductivebreast
    extracellular RGN may play a role as a suppressor in the growth of mammary epithelial cells with TP53 loss, providing a novel strategy for cancer
    ANIMAL & CELL MODELS