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FLASH GENE
Symbol RGN contributors: mct - updated : 09-05-2012
HGNC name regucalcin (senescence marker protein-30)
HGNC id 9989
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus regucalcin
ortholog to murine Rgn
homolog to Drosophila regucalcin
homolog to C.elegans C08F11.5
intraspecies homolog to senescence marker protein 30
Homologene
FAMILY
  • SMP-30/CGR1 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • playing an important role in calcium homeostasis
  • playing a role in aging and in the regulation of the enzymatic activity in the liver
  • has protective effects against age-associated oxidative stress in brain and lungs
  • cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical warfare nerve agents
  • glucolactonase, which is a key enzyme for l-ascorbic acid (vitamin C) biosynthesis
  • has a suppressive effect on calcium signaling from the cytoplasm to the nucleus in the proliferative cells
  • plays an important role as a regulatory protein in cell signaling system, and it is proposed to play a pivotal role in keep of cell homeostasis and function
  • calcium (Ca(2)(+))-binding protein which regulates intracellular Ca(2)(+) homeostasis by modulating the activity of enzymes regulating Ca(2)(+) concentration and enhancing Ca(2)(+)-pumping activity
  • may have a role in male reproductive function, particularly in the control of spermatogenesis
  • plays a role in Ca(2+) homeostasis by modulating a number of Ca(2+)-dependent proteins
  • also plays a cyto-protective role and its decrease is linked to age-related diseases and cell death
  • having a cardio-protective role with anti-oxidative and anti-aging effects
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text calcium
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • prevented cardiac hypertrophy and diastolic dysfunction by AGT
  • cell & other
    REGULATION
    repressed by aging (age-associated down-regulation)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may contribute to the worsening of glucose tolerance that occurs in normal aging
    constitutional     --low  
    in nonalcoholic fatty liver disease
    tumoral     --low  
    in breast and prostate cancer cases and the regulation of its expression by sex steroid hormones suggest that it may be associated with development and progression of these tumors (
    constitutional     --over  
  • cardiac-specific overexpression of RGN inhibited AGT -induced cardiac adverse remodeling
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    therapeutic target to prevent cardiac hypertrophy and remodeling due to hypertension
    ANIMAL & CELL MODELS