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FLASH GENE
Symbol RGMB contributors: mct/npt - updated : 16-01-2018
HGNC name RGM domain family, member B
HGNC id 26896
Location 5q21.1      Physical location : 98.104.998 - 98.132.196
Synonym name
  • repulsive guidance molecule B
  • membrane-associated [glycosyl-phosphatidylinositol (GPI)-anchored] protein
  • Synonym symbol(s) DRAGON, FLJ90406, MGC86970
    DNA
    TYPE functioning gene
    STRUCTURE 27.20 kb     5 Exon(s)    1 Copie(s)
    regulatory sequence Promoter
    text structure a promoter region binding to the DNA binding domain of DRGX
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4601 - 478 - Samad (2005)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousbrainmidbrain  highly
    Reproductivemale systemprostate  highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text optic tectum of the midbrain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • GPI anchored glycoprotein
  • a N terminal RGM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • repulsive guidance molecule (RGM) family
  • CATEGORY signaling , receptor nuclear
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • repulsive and specific guiding activity in the optic tectum
  • glycosylphosphatidylinositol-anchored member of the repulsive guidance molecule family, enhancing BMP but not TGFbeta signaling
  • GPI-anchored membrane protein, inhibiting BMP signaling in C2C12 myoblasts (Kanomata 2009)
  • myelin-derived inhibitor of axon growth in the CNS (Liu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text development of nervous (visual) system
    PATHWAY
    metabolism
    signaling
    a component RGM/neogenin regulates cell fate by controlling the DAPK1 activity) (Fujita 2008)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for neogenin (NEO1)
  • direct interaction with BMP ligands and receptors (indicates that it is a BMP co-receptor that potentiates BMP signaling)
  • binds directly to BMP2 and BMP4 but not to BMP7 or other TGFbeta ligands
  • associates directly with BMP type I (ALK2, ALK3, and ALK6) and type II (ActRII and ActRIIB) receptors, and its signaling is reduced by dominant negative SMAD1 and ALK3 or -6 receptors
  • interacts with itself homophilically
  • inhibition of BMP2 and BMP4 that inhibits hepcidin expression in these cells (Andriopoulos 2009)
  • RGMB-NEO1-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the olfactory epithelium (OE)
  • cell & other
    REGULATION
    Other transcriptionally regulated by DRGX, and it is coexpressed with DRGX in embryonic dorsal root ganglion and spinal cord
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS