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FLASH GENE
Symbol RGMB contributors: mct/npt - updated : 16-01-2018
HGNC name RGM domain family, member B
HGNC id 26896
Location 5q15      Physical location : 98.104.998 - 98.132.196
Synonym name
  • repulsive guidance molecule B
  • membrane-associated [glycosyl-phosphatidylinositol (GPI)-anchored] protein
  • Synonym symbol(s) DRAGON, FLJ90406, MGC86970, DKFZp434P228
    DNA
    TYPE functioning gene
    STRUCTURE 27.86 kb     5 Exon(s)    1 Copie(s)
    regulatory sequence Promoter
    text structure a promoter region binding to the DNA binding domain of DRGX
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4601 - 478 - 2019 31061392
    5 - 4480 - 478 - 2019 31061392
    5 - 4684 - 478 - 2019 31061392
    5 - 4436 - 477 - 2019 31061392
    3 - 4463 - 437 - 2019 31061392
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Nervousnervecranial nerve  highly Homo sapiens
    Reproductivemale systemprostate  highly
    Skin/Tegumentskin   highly
    Urinarykidneytubule  highly Mus musculus
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell Mus musculus
    Visualganglion cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text optic tectum of the midbrain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • GPI anchored glycoprotein
  • a N terminal RGM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • repulsive guidance molecule (RGM) family
  • CATEGORY signaling , receptor nuclear
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • repulsive and specific guiding activity in the optic tectum
  • glycosylphosphatidylinositol-anchored member of the repulsive guidance molecule family, enhancing BMP but not TGFbeta signaling
  • GPI-anchored membrane protein, inhibiting BMP signaling in C2C12 myoblasts (Kanomata 2009)
  • myelin-derived inhibitor of axon growth in the CNS (Liu 2009)
  • may impair tubular epithelial integrity and induce epithelial apoptosis
  • is not essential for normal gonadal function
  • important role for a novel innate pathway in regulating type 2 inflammation in patients with allergic asthma involving RGMB and RGMB-expressing cells, such as interstitial macrophages and bronchial epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text development of nervous (visual) system
    PATHWAY
    metabolism
    signaling
    a component RGM/neogenin regulates cell fate by controlling the DAPK1 activity) (Fujita 2008)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for neogenin (NEO1)
  • direct interaction with BMP ligands and receptors (indicates that it is a BMP co-receptor that potentiates BMP signaling)
  • binds directly to BMP2 and BMP4 but not to BMP7 or other TGFbeta ligands
  • associates directly with BMP type I (ALK2, ALK3, and ALK6) and type II (ActRII and ActRIIB) receptors, and its signaling is reduced by dominant negative SMAD1 and ALK3 or -6 receptors
  • interacts with itself homophilically
  • inhibition of BMP2 and BMP4 that inhibits hepcidin expression in these cells (Andriopoulos 2009)
  • RGMB-NEO1-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the olfactory epithelium (OE)
  • RGMB binds an extracellular domain of CTLA4, and specifically strengthens the binding of the monomeric, soluble form of CTLA4 (sCTLA-4) to CD80
  • when RGMB is phosphorylated by the extracellular tyrosine kinase PKDCC, phosphorylated RGMB (p-RGMb) is internalized and carries LRP5 towards intracellular compartments
  • cell & other
    REGULATION
    Other transcriptionally regulated by DRGX, and it is coexpressed with DRGX in embryonic dorsal root ganglion and spinal cord
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colon cancer tissues compared to control tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    potential therapeutic target for CRC treatment
    ANIMAL & CELL MODELS