protein
| ligand for neogenin (NEO1) |
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direct interaction with BMP ligands and receptors (indicates that it is a BMP co-receptor that potentiates BMP signaling) |
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binds directly to BMP2 and BMP4 but not to BMP7 or other TGFbeta ligands |
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associates directly with BMP type I (ALK2, ALK3, and ALK6) and type II (ActRII and ActRIIB) receptors, and its signaling is reduced by dominant negative SMAD1 and ALK3 or -6 receptors |
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interacts with itself homophilically |
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inhibition of BMP2 and BMP4 that inhibits hepcidin expression in these cells (Andriopoulos 2009) |
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RGMB-NEO1-mediated cell-cell interactions between newly born neurons and progenitor cells control the ratio of glia and neurons produced in the olfactory epithelium (OE) |
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RGMB binds an extracellular domain of CTLA4, and specifically strengthens the binding of the monomeric, soluble form of CTLA4 (sCTLA-4) to CD80 |
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when RGMB is phosphorylated by the extracellular tyrosine kinase PKDCC, phosphorylated RGMB (p-RGMb) is internalized and carries LRP5 towards intracellular compartments |