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FLASH GENE
Symbol RDH11 contributors: mct - updated : 22-03-2011
HGNC name retinol dehydrogenase 11 (all-trans and 9-cis)
HGNC id 17964
Location 14q24.1      Physical location : 68.143.520 - 68.162.510
Synonym name
  • CGI-82 protein/HCV core-binding protein
  • androgen-regulated short-chain dehydrogenase/reductase 1
  • Synonym symbol(s) PSDR1, MDT1, ARSDR1, RALR1, SCALD, CGI-82, HCBP12, FLJ32633
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text in the 3'-RDH11-5' 5'RDH12-3' orientation
    STRUCTURE 18.99 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   HRE
    text structure potential androgen-response element
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC122438 14q23.3 similar to RIKEN cDNA 1110013H04 LOC387993 14 hypothetical gene supported by BC033546 GPHN 14q23.1/14q23,3 gephyrin C14orf54 14 chromosome 14 open reading frame 54 LOC260329 14q23 splicing factor 3b, subunit 4, 49kD pseudogene MPP5 14q23.3 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) ATP6V1D 14q23-q24.2 ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D EIF2S1 14q21.3 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa PLEK2 14q23.1-q23.2 pleckstrin 2 FLJ33387 14q24.1 hypothetical protein FLJ33387 PIGH 2p21-p16 phosphatidylinositol glycan, class H LOC390490 14 similar to Ac2-008 ARG2 14q24.1-q24.3 arginase, type II VTI1B 14q23,3 vesicle transport through interaction with t-SNAREs homolog 1B (yeast) COX7A3P 14 cytochrome c oxidase subunit VIIa polypeptide 3 pseudogene RDH11 14q23-q24.3 retinol dehydrogenase 11 (all-trans and 9-cis) RPL21P9 14q23.3 ribosomal protein L21 pseudogene 9 RDH12 14q23.3 retinol dehydrogenase 12 (all-trans and 9-cis) ZFYVE26 14q23.2-q24.2 zinc finger, FYVE domain containing 26 RAD51L1 14q24.1 RAD51-like 1 (S. cerevisiae) RPL7AP5 14 ribosomal protein L7a pseudogene 5 RPL12P7 14 ribosomal protein L12 pseudogene 7 ZFP36L1 14q22-q24 zinc finger protein 36, C3H type-like 1 MAGOHP 14 mago-nashi homolog, proliferation-associated pseudogene (Drosophila) BLZF2P 14q24.1 basic leucine zipper nuclear factor 2 pseudogene ACTN1 14q24.1 actinin, alpha 1
    regionally located . ~30kb from the RDH12 gene . at the locus for recessive blinding disease, LCA3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2587 - 318 - 2002 12036956
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver     Homo sapiens
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate  highly
     male systemtestis    Homo sapiens
    Urinarykidney    
    Visualeyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell
    VisualMuller cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • short chain dehydrogenase domain
  • a co-factor binding site (GXXXGXG)
  • catalytic residues (YXXXK)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • playing a role in the pathogenesis of prostate carcinoma
  • might play a role in the regulation of retinoid homeostasis in prostate
  • catalyzes the reduction of all-trans-retinal and 9,11,13-cis-retinal isomers
  • may function in the recycling of the visual chromophore 11-cis-retinal after photoisomerization by a bleaching light, a pathway referred to as the visual cycle
  • potentially having a housekeeping function
  • with RDH12, can enzymatically reduce toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    NADPH
    protein
    cell & other
    REGULATION
    activated by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    and remarkably constant during development and oxidative stress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS