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FLASH GENE
Symbol RDH11 contributors: mct - updated : 22-03-2011
HGNC name retinol dehydrogenase 11 (all-trans and 9-cis)
HGNC id 17964
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver     Homo sapiens
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate  highly
 male systemtestis    Homo sapiens
Urinarykidney    
Visualeyeretina    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningretinal pigment epithelium (RPE)  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveepithelial cell
VisualMuller cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short chain dehydrogenase domain
  • a co-factor binding site (GXXXGXG)
  • catalytic residues (YXXXK)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • playing a role in the pathogenesis of prostate carcinoma
  • might play a role in the regulation of retinoid homeostasis in prostate
  • catalyzes the reduction of all-trans-retinal and 9,11,13-cis-retinal isomers
  • may function in the recycling of the visual chromophore 11-cis-retinal after photoisomerization by a bleaching light, a pathway referred to as the visual cycle
  • potentially having a housekeeping function
  • with RDH12, can enzymatically reduce toxic lipid peroxidation products such as 4-hydroxynonenal (4-HNE)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    NADPH
    protein
    cell & other
    REGULATION
    activated by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    and remarkably constant during development and oxidative stress
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS