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FLASH GENE

Symbol

RBP2

contributors: mct/npt/pgu - updated : 01-09-2009

HGNC name	retinol binding protein 2, cellular
HGNC id	9920

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q23      Physical location : 139.171.726 - 139.195.352
Synonym name	cellular retinol-binding protein II
Synonym symbol(s)	CRBP2, RBPC2, CRBPII, CRABP-II, C

DNA

TYPE	functioning gene
STRUCTURE	23.63 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	a direct repeat 1 (DR-1)-like nuclear receptor response element in the proximal promoter region and endogenous hepatocyte nuclear factor-4alpha (HNF-4alpha) was a major transcription factor binding to the DR-1-like element

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004164 4 - 700 NP_004155 15.6 134 - 1999 10191085

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine

cells

System Cell Pubmed Species Stage Rna symbol Digestive enterocyte

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	enterocyte

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

a single eight-stranded continuously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site

mono polymer

monomer

HOMOLOGY

Homologene

FAMILY	calycin superfamily
	fatty-acid binding protein (FABP) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	involved in the transport of vitamin A in the small intestinal epithelium
	plays important physiological roles in intestinal absorption, transport, and metabolism of vitamin A
	play different roles in the maintenance of vitamin A homeostasis
	its histone demethylase activity is linked to tumorigenesis
	regulates proliferation, senescence, and differentiation, which are processes deregulated in cancer

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

vitamin

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	retinol binding
	interacting with HNF4A (HNF-4alpha is an important transcriptional factor that regulates its gene expression)
	interacting with RB (RBP2 inhibits senescence and differentiation in RB-defective tumor cells, and loss of RBP2 inhibits formation of RB-defective endocrine tumors, suggesting that RBP2 also acts downstream of RB)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function inhibits proliferation and induces senescence

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     potential target for cancer therapy, and RBP2-inhibitory drugs, should they be developed, would have anticancer activity

ANIMAL & CELL MODELS