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FLASH GENE
Symbol RBP2 contributors: mct/npt/pgu - updated : 01-09-2009
HGNC name retinol binding protein 2, cellular
HGNC id 9920
Location 3q23      Physical location : 139.171.726 - 139.195.352
Synonym name cellular retinol-binding protein II
Synonym symbol(s) CRBP2, RBPC2, CRBPII, CRABP-II, C
DNA
TYPE functioning gene
STRUCTURE 23.63 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure
  • a direct repeat 1 (DR-1)-like nuclear receptor response element in the proximal promoter region and endogenous hepatocyte nuclear factor-4alpha (HNF-4alpha) was a major transcription factor binding to the DR-1-like element
  • MAPPING cloned Y linked N status confirmed
    Physical map
    NPM1P17 3q22.3 nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 17 SOX14 3q23 SRY (sex determining region Y)-box 14 LOC344829 3q22.3 similar to Heat shock cognate 71 kDa protein CLDN18 3q22.3 claudin 18 FLJ32844 3q22.3 hypothetical protein FLJ32844 alpha4GnT 3p14.3 hypothetical protein FLJ32844 DBR1 3q22.3 debranching enzyme homolog 1 (S. cerevisiae) HSPC056 3q22.3 HSPC056 protein TXL-2 3q22.3 thioredoxin-like 2 MRAS 3q22.3 muscle RAS oncogene homolog CHR3SYT 3q22.3 chr3 synaptotagmin BITE 3q22-q23 p10-binding protein FAIM 3q23 Fas apoptotic inhibitory molecule LOC256374 3q22.3 similar to peptidylprolyl isomerase A PIK3CB 3q22-q23 phosphoinositide-3-kinase, catalytic, beta polypeptide LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2 TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036 LOC391584 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RASA2 3q22-q23 RAS p21 protein activator 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 700 15.6 134 - 1999 10191085
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveenterocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text enterocyte
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • a single eight-stranded continuously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the transport of vitamin A in the small intestinal epithelium
  • plays important physiological roles in intestinal absorption, transport, and metabolism of vitamin A
  • play different roles in the maintenance of vitamin A homeostasis
  • its histone demethylase activity is linked to tumorigenesis
  • regulates proliferation, senescence, and differentiation, which are processes deregulated in cancer
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism vitamin
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinol binding
  • interacting with HNF4A (HNF-4alpha is an important transcriptional factor that regulates its gene expression)
  • interacting with RB (RBP2 inhibits senescence and differentiation in RB-defective tumor cells, and loss of RBP2 inhibits formation of RB-defective endocrine tumors, suggesting that RBP2 also acts downstream of RB)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    inhibits proliferation and induces senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for cancer therapy, and RBP2-inhibitory drugs, should they be developed, would have anticancer activity
    ANIMAL & CELL MODELS