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FLASH GENE
Symbol RBP2 contributors: mct/npt/pgu - updated : 01-09-2009
HGNC name retinol binding protein 2, cellular
HGNC id 9920
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a single eight-stranded continuously hydrogen-bonded antiparallel beta-barrel which encloses an internal ligand binding site
  • mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • calycin superfamily
  • fatty-acid binding protein (FABP) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the transport of vitamin A in the small intestinal epithelium
  • plays important physiological roles in intestinal absorption, transport, and metabolism of vitamin A
  • play different roles in the maintenance of vitamin A homeostasis
  • its histone demethylase activity is linked to tumorigenesis
  • regulates proliferation, senescence, and differentiation, which are processes deregulated in cancer
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism vitamin
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • retinol binding
  • interacting with HNF4A (HNF-4alpha is an important transcriptional factor that regulates its gene expression)
  • interacting with RB (RBP2 inhibits senescence and differentiation in RB-defective tumor cells, and loss of RBP2 inhibits formation of RB-defective endocrine tumors, suggesting that RBP2 also acts downstream of RB)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    inhibits proliferation and induces senescence
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential target for cancer therapy, and RBP2-inhibitory drugs, should they be developed, would have anticancer activity
    ANIMAL & CELL MODELS