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FLASH GENE
Symbol RBM4 contributors: mct - updated : 04-01-2012
HGNC name RNA binding motif protein 4
HGNC id 9901
Location 11q13      Physical location : 66.406.137 - 66.413.940
Synonym name zinc finger CCHC-type and RNA binding motif 3A
Synonym symbol(s) LARK, MGC75138, RBM4A, ZCCHC21, ZCRB3A
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KLC2 11q13.1 pyruvate carboxylase RAB1B 11q12 RAB1B, member RAS oncogene family MGC50896 11q13.1 hypothetical protein MGC50896 YIF1 11q13 Yip1 interacting factor homolog (S. cerevisiae) MGC33486 11q13.1 hypothetical protein MGC33486 LOC387783 11 LOC387783 CD164L1 11q13 CD164 sialomucin-like 1 RIN1 11q13.2 Ras and Rab interactor 1 BRMS1 14q13.1 breast cancer metastasis-suppressor 1 B3GNT6 11q13.1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 SLC29A2 11q13 solute carrier family 29 (nucleoside transporters), member 2 LOC387784 11 LOC387784 NXF 11q13 HLH-PAS transcription factor NXF MRPL11 11q13.3 mitochondrial ribosomal protein L11 MGC35521 11q13.1 pellino 3 alpha DPP3 11q12-q13.1 dipeptidylpeptidase 3 BBS1 11q13 Bardet-Biedl syndrome 1 LOC254359 11q13.1 hypothetical protein LOC254359 ACTN3 11q13 actinin, alpha 3 CTSF 11q13.1-q13.3 cathepsin F FLJ10786 11q13.1 hypothetical protein FLJ10786 CCS 11q13 copper chaperone for superoxide dismutase RBM14 11q12.1 RNA binding motif protein 14 MGC15912 11q13.1 hypothetical protein MGC15912 RBM4 11q13 RNA binding motif protein 4 MGC10871 11q13 hypothetical protein similar to RNA-binding protein lark SPTBN2 11q13 spectrin, beta, non-erythrocytic 2 FLJ22531 11q13.1 hypothetical protein FLJ22531 RCE1 11q13 RCE1 homolog, prenyl protein protease (S. cerevisiae) PC 11q13.3 pyruvate carboxylase MGC3103
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouth   highly
Lymphoid/Immunethymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two copies of the RRM motif
  • a retroviral type (RET) zinc finger domain
  • a CCHC-type zinc finger
  • mono polymer polymer
    HOMOLOGY
    interspecies homolog to Drosophila lark
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text may undergo continuous nucleocytoplasmic shuttling
    basic FUNCTION
  • having a role as a modulator of alternative splicing of mRNAs
  • may be playing a role in the circadian system
  • antagonizes the activity of splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha-tropomyosin
  • may synergize its effect on muscle cell-specific alternative splicing by down-regulating PTBP1 expression and antagonizing the activity of PTBP1 in exon selection, which highlights a hierarchical role for RBM4 in a splicing cascade that regulates myogenesis
  • modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation
  • may have role in promoting pancreas cell differentiation and endocrine function, essentially via alternative splicing regulation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein binds TNPO3, which mediates nuclear import of the protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryonic pancreases of Rbm4-deficient mice showed reduced expression or aberrant splicing of many transcripts encoding factors required for pancreas cell differentiation and function