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FLASH GENE
Symbol RBM4 contributors: mct - updated : 04-01-2012
HGNC name RNA binding motif protein 4
HGNC id 9901
Location 11q13      Physical location : 66.406.137 - 66.413.940
Synonym name zinc finger CCHC-type and RNA binding motif 3A
Synonym symbol(s) LARK, MGC75138, RBM4A, ZCCHC21, ZCRB3A
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouth   highly
Lymphoid/Immunethymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two copies of the RRM motif
  • a retroviral type (RET) zinc finger domain
  • a CCHC-type zinc finger
    • mono polymer polymer
    HOMOLOGY
    interspecies homolog to Drosophila lark
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text may undergo continuous nucleocytoplasmic shuttling
    basic FUNCTION
  • having a role as a modulator of alternative splicing of mRNAs
  • may be playing a role in the circadian system
  • antagonizes the activity of splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha-tropomyosin
  • may synergize its effect on muscle cell-specific alternative splicing by down-regulating PTBP1 expression and antagonizing the activity of PTBP1 in exon selection, which highlights a hierarchical role for RBM4 in a splicing cascade that regulates myogenesis
  • modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation
  • may have role in promoting pancreas cell differentiation and endocrine function, essentially via alternative splicing regulation
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein binds TNPO3, which mediates nuclear import of the protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryonic pancreases of Rbm4-deficient mice showed reduced expression or aberrant splicing of many transcripts encoding factors required for pancreas cell differentiation and function