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FLASH GENE
Symbol RBM4 contributors: mct - updated : 04-01-2012
HGNC name RNA binding motif protein 4
HGNC id 9901
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two copies of the RRM motif
  • a retroviral type (RET) zinc finger domain
  • a CCHC-type zinc finger
  • mono polymer polymer
    HOMOLOGY
    interspecies homolog to Drosophila lark
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    text may undergo continuous nucleocytoplasmic shuttling
    basic FUNCTION
  • having a role as a modulator of alternative splicing of mRNAs
  • may be playing a role in the circadian system
  • antagonizes the activity of splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha-tropomyosin
  • may synergize its effect on muscle cell-specific alternative splicing by down-regulating PTBP1 expression and antagonizing the activity of PTBP1 in exon selection, which highlights a hierarchical role for RBM4 in a splicing cascade that regulates myogenesis
  • modulates alternative splicing of muscle-specific mRNA isoforms during muscle cell differentiation
  • may have role in promoting pancreas cell differentiation and endocrine function, essentially via alternative splicing regulation
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein binds TNPO3, which mediates nuclear import of the protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • embryonic pancreases of Rbm4-deficient mice showed reduced expression or aberrant splicing of many transcripts encoding factors required for pancreas cell differentiation and function