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FLASH GENE

Symbol

RBM10

contributors: mct/npt - updated : 20-04-2022

HGNC name	RNA binding motif protein 10
HGNC id	9896

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease
Location	Xp11.3      Physical location : 47.004.630 - 47.046.211
Synonym name	DNA segment,single copy expressed clone 1
	RNA-binding protein S1-1
	G patch domain-containing protein 9
	epididymis secretory sperm binding protein
Synonym symbol(s)	KIAA0122, DXS8237E, MGC997, MGC1132, ZRANB5, GPATC9, GPATCH9, S1-1

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	its 3' end lies within 20 kb upstream of UBE1
STRUCTURE	41.58 kb     24 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

in a region duplicated from Xp11.3-p11.23, 20kb upstream of UBE1 but not escaping to inactivation

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005676 24 splicing 3415 NP_005667 103.5 930 - Coleman (1996) containing a stretch of triplet repeats (GAG -> Glu) in the coding region NM_152856 23 splicing 3190 NP_690595 94.4 852 - Coleman (1996) lacking a coding exon using an alternate donor splice site in another coding exon maintaining the same reading frame missing a stretch of triplet repeats (GAG -> Glu) in the coding region

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Endocrine pancreas         Nervous brain       highly Reproductive male system prostate       Respiratory lung       highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two tandem RNP motifs
	a repeat of five octamers and an emphipathic alpha-helix
	a zinc finger motif
	a G patch
	two RNA recognition motif (RRM) domains

HOMOLOGY

interspecies	ortholog to murine Rbm10
	homolog to Drosophila CG4896

intraspecies

paralog to RBM5

Homologene

FAMILY

RBM proteins family of apoptosis modulators

CATEGORY

RNA associated , tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner (Inoue 2008)

basic FUNCTION	with CASP3, involved in the last steps of the apoptotic cascade in breast cancer (Martín-Garabato 2008)
	possesses multiple nucleolar and cellular functions in vascular smooth muscle cells (VSMC)(Mueller 2009)
	regulates AT1 receptor gene (AGTR1) expression via transcriptional and posttranscriptional mechanisms (Mueller 2009)
	is an important regulator of alternative splicing
	nuclear RNA-binding protein with domains characteristic of RNA processing proteins
	RBM10 promotes exon skipping of FAS pre-mRNA as well as selection of an internal 5'-splice site in BCLX pre-mRNA
	RBM10 can function as an apoptosis modulator and cytokine expression regulator
	is a regulator of alternative splicing in apoptosis and inflammation
	anti-hypertrophy mechanism mediated by RBM10 in the heart that is directly linked to heart failure (HF)
	acts as a tumor suppressor in osteosarcoma
	nuclear RNA-binding protein (RBP) that regulates the alternative splicing of primary transcripts
	is involved in alternative splicing and modifies mRNA post-transcriptionally

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	binding to RNA homopolymers with a preference for G and U polyribonucleotides

small molecule	metal binding,
	Zn2+

protein	autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay
	can induce apoptosis and inhibit cancer cell proliferation by activating TP53
	inhibits cancer cell proliferation and induces apoptosis in part by blocking the MDM2-TP53 feedback loop
	RBM10 role in TP53-dependent cancer prevention
	regulates human TERT gene splicing and inhibits pancreatic cancer progression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

TARP

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   leads to increased apoptosis in vascular smooth muscle cells (VSMC) and decreases VSMC proliferation (Mueller 2009) tumoral germinal mutation       contribute to lung adenocarcinoma (LUAD) pathogenesis, at least in large part, by deregulating splicing constitutional     --low   during cardiac hypertrophy (CH) and heart failure (HF) tumoral     --over   induced osteosarcoma cell apoptosis via the inhibition of BCL2, the activation of CASP3, and the transcription and production of TNF 0)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS