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FLASH GENE
Symbol RBM10 contributors: mct/npt - updated : 20-04-2022
HGNC name RNA binding motif protein 10
HGNC id 9896
ASSOCIATED DISORDERS
corresponding disease(s) TARP
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
leads to increased apoptosis in vascular smooth muscle cells (VSMC) and decreases VSMC proliferation (Mueller 2009)
tumoral germinal mutation      
contribute to lung adenocarcinoma (LUAD) pathogenesis, at least in large part, by deregulating splicing
constitutional     --low  
during cardiac hypertrophy (CH) and heart failure (HF)
tumoral     --over  
induced osteosarcoma cell apoptosis via the inhibition of BCL2, the activation of CASP3, and the transcription and production of TNF 0)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS