| basic FUNCTION
| modulate immune system function through its binding to the chemerin receptor |
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adipokine chemerin likely regulating adipocyte function by autocrine/paracrine mechanisms |
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adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism |
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modulate immune system function through its binding to the chemerin receptor |
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regulate both adipocyte differentiation and lipid metabolism |
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may be involved in both the initiation and resolution of inflammation (Yoshimura 2008) |
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adipokine that affects adipogenesis and glucose homeostasis in adipocytes and increases with BMI in humans (Sell 2009) |
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induces insulin resistance in skeletal muscle cells at the level of insulin receptor substrate 1, Akt and glycogen synthase kinase 3 phosphorylation, and glucose uptake (Sell 2009) |
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may be involved in the development of the metabolic syndrome (Bozaoglu 2009) |
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role for chemerin as a stimulator of angiogenesis (Bozaoglu 2010) |
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activates key survival and angiogenic signalling cascades like MAPK and Akt pathways (Kaur 2010) |
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inducing functional angiogenesis in human endothelial cells by promoting migration and capillary tube formation, and activation of endothelial gelatinases (MMP-2/-9) (Kaur 2010) |
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adipocytokine which plays a role on inflammation and adipocytes metabolism  |
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plays a role not only in the differentiation of adipocytes but also in the inflammatory responses of immune cells such as dendritic cells and macrophages |
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might play a compensate role in the pathogenesis of obesity and/or type II diabetes-related inflammatory vascular diseases |
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plays an inhibitory role on inflammatory state of vascular endothelial cells |
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roles for RARRES2/CMKLR1-mediated in dental epithelial-dental mesenchymal (DE-DM) signaling during tooth morphogenesis |
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oxidative stress mediates RARRES2-induced autophagy in endothelial cells |
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is an antimicrobial agent in human skin |
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in host defense, chemerin plays dual roles as a broad spectrum antimicrobial protein and as a leukocyte attractant for macrophages, dendritic cells, and NK cells |
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is a novel adipokine linked to inflammation |
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role of genetic variation in RARRES2 in the regulation of circulating serum chemerin |
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physiologic role for RARRES2 in skin barrier defense against microbial pathogens |
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may play an important role in regulating mitochondrial remodelling and function in skeletal muscle |
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RARRES2 stimulated vascular smooth muscle cells proliferation and carotid intimal hyperplasia through activation of the mitogen-activated protein kinase signaling pathway, which may lead to vascular inflammation and remodeling, and is relevant to proliferative cardiovascular diseases |
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is a novel tumor suppressor for adrenocortical carcinoma (ACC), which can function through an immune-independent mechanism |
