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FLASH GENE
Symbol RARRES2 contributors: mct/npt - updated : 12-07-2017
HGNC name retinoic acid receptor responder (tazarotene induced) 2
HGNC id 9868
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in the adipose depots of obese compared with lean animals and was markedly elevated during differentiation of fibroblasts into mature adipocytes (Bozaoglu 2010)
constitutional     --over  
in obese subjects
tumoral     --low  
in multiple cancer types
constitutional     --over  
serum RARRES2 concentrations were significantly higher in atrial fibrillation patients compared with healthy controls
constitutional     --over  
circulating chemerin was increased in overweight compared with normal weight polycystic ovary syndrome (PCOS) patients
constitutional     --over  
circulating levels of the RARRES2 are elevated in Lipodystrophy (LD), as well as independently and positively associated with HbA1c and CRP
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • serum RARRES2 may be used as a novel prognostic marker for adrenocortical carcinoma (ACC)
  • is a novel biomarker of dilated cardiomyopathy
  • may play a role as predictive biomarker for pre-eclampsia and be an important causative factor in the pathogenesis of pre-eclampsia
  • Therapy target
    ANIMAL & CELL MODELS