| basic FUNCTION
| involved in the production of superoxide in neutrophils |
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putative regulator of mitogen-induced cytoskeletal changes essential for membrane ruffling and C-jun aminoterminal kinase JNK |
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regulator of actin filament at the plasma membrane to produce lamellipodia and membrane ruffles |
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key downstream target in Ras signaling |
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linking growth factor receptor to the activator of actin polymerization |
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activating JNK signaling pathway |
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reduction of oxygen to O-2 at the expense of NADPH,the O2-generated is the precursor of potent oxidants used to kill the invading microorganisms |
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have distinct roles in regulating cell morphology, migration and invasion, but are not essential for macrophage migration or chemotaxis |
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plays a critical role in host defense |
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plays an important role in cell migration with activation of membrane ruffling, whereas the other members of the Rho family, like RHOA and CDC42, mediate stress fibers and filopodia formation, respectively |
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in hematopoietic cells regulates leukocyte lineage distribution and in nonhematopoietic cells might contribute to regulating circulating neutrophil counts  |
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play essential roles in coordinating directional migration and superoxide production during neutrophil responses to chemoattractants |
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RAC1 and RAC2 GTPases are essential for normal bone marrow erythropoiesis but that they are dispensable for erythropoiesis in the spleen, implying different signaling pathways for homeostatic and stress erythropoiesis |
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important role in mature osteoclasts |
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required for the formation of neutrophil extracellular traps |
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NCF1 and RAC2 accumulate only transiently at the phagosome at the onset of NADPH activity and detach from the phagosome before the end of ROS production |
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controls tumor growth, metastasis and M1-M2 macrophage differentiation |
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important role for RAC2 in maintaining mitochondrial integrity |
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