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FLASH GENE
Symbol RAC2 contributors: mct/pgu - updated : 04-11-2016
HGNC name ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
HGNC id 9802
ASSOCIATED DISORDERS
corresponding disease(s) NIDS
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --low  
in severe congenital neutropenia
tumoral     --low  
exhausts the leukemic stem cells pool, through impairment of oncogene-induced proliferation and survival signals
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS
  • Rac2(-/-) mice are of normal size and have normal tooth eruption, but femoral cortical thickness was significantly greater compared to wild-type mice