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FLASH GENE
Symbol RAB6A contributors: mct/shn/pgu - updated : 20-09-2015
HGNC name RAB6A, member RAS oncogene family
HGNC id 9786
Location 11q13.4      Physical location : 73.386.689 - 73.472.201
Synonym name
  • oncogene RAB6
  • ras-related protein rab 6a
  • GTP-binding protein RAB6A
  • GTP-binding protein RAB6B
  • Rab6A variant 3
  • Synonym symbol(s) RAB6, RAB6B, Rab-6
    DNA
    TYPE functioning gene
    STRUCTURE 85.52 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D11S1314 - D11S916 - RAB6A - D11S2371 - D11S4207 - qter
    Physical map
    FOLR2 11q13.3-q13.5 folate receptor 2 (fetal) INPPL1 11q23 inositol polyphosphate phosphatase-like 1 PHOX2A 11q13.3-q13.4 paired-like (aristaless) homeobox 2a LOC220077 11q13.3 hypothetical gene supported by AF229166 LOC390223 11 similar to Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 snRNP auxiliary factor small subunit) SKD3 11q13.3 suppressor of potassium transport defect 3 ART2P 11q13 ADP-ribosyltransferase 2 pseudogene (RT6 antigen homolog, rat) PDE2A 11cen-q12.1 phosphodiesterase 2A, cGMP-stimulated CENTD2 11q13.3 centaurin, delta 2 STARD10 11q13 START domain containing 10 FLJ00012 11q13.3 hypothetical protein FLJ00012 KIAA0769 11q13.2 hypothetical protein FLJ00012 P2RY2 11q13.5-q14.1 purinergic receptor P2Y, G-protein coupled, 2 P2RY6 11q13.5 pyrimidinergic receptor P2Y, G-protein coupled, 6 ARHGEF17 11q13.3-q13.5 Rho guanine nucleotide exchange factor (GEF) 17 TNFRSF19L 11q13,3 tumor necrosis factor receptor superfamily, member 19-like LOC387786 11 LOC387786 KIAA0280 11q13.3 KIAA0280 protein PLEKHB1 11q13.5-q14.1 pleckstrin homology domain containing, family B (evectins) member 1 RAB6A 2q14-q21 RAB6A, member RAS oncogene family LOC268276 11q13 musashi 1 pseudogene MRPL48 11q13.2 mitochondrial ribosomal protein L48 E2IG2 11q13.3 E2IG2 protein FLJ11848 11q13.3 hypothetical protein FLJ11848 TSARG6 11q13.3 testis spermatogenesis apoptosis-related protein 6 UCP2 11q13 uncoupling protein 2 (mitochondrial, proton carrier) UCP3 11q13 uncoupling protein 3 (mitochondrial, proton carrier) DKFZP586P0123 11q13.3 DKFZP586P0123 protein PME-1 11q13.3 protein phosphatase methylesterase-1 LOC283208 FLJ32029 KCNE3 11q13-q14 potassium voltage-gated channel, Isk-related family, member 3 HCP27 11q13.3 cytochrome c, somatic pseudogene LOC387787 11 similar to RIKEN cDNA 2610209A20 POLD3 11q14 similar to RIKEN cDNA 2610209A20 BNF1 FLJ22596 11q13.3 hypothetical protein FLJ22596 LOC387788 11 similar to ribosomal protein S12 KIAA1991 11q13.3 hypothetical protein KIAA1991 KIAA0102 11q13.3 hypothetical protein KIAA1991 LOC387789 11 LOC387789 NEU3 11q13.5 sialidase 3 (membrane sialidase) LOC390224 11 similar to olfactory receptor MOR101-2 LOC341152 11q13.3 similar to olfactory receptor MOR101-1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3419 23.6 208 - PMID: 19141279
    8 splicing 3419 23.3 208 - PMID: 19141279
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Nervousbrain    
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • binding domains of three RAB6A effector proteins: GOPC, BICD2, and DCTN1
  • HOMOLOGY
    interspecies homolog to murine Rab 6
    Homologene
    FAMILY
  • Rab6 family
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulates retrograde membrane traffic from endosomes to the Golgi apparatus and from the Golgi to the endoplasmic reticulum (ER)
  • regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors
  • key regulator in the retrograde transfer from endosomes via the Golgi to the ER
  • regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT1 and COG
  • implicated in dynein-mediated vesicle movement at the Golgi apparatus and interact with a plethora of effector proteins
  • RAB1A and RAB6A may be involved in the regulation of the retinal adaptation
  • RAB33B/RAB6A regulated intra-Golgi retrograde trafficking pathway must coexist with other Golgi trafficking pathways
  • important role during neuritogenesis
  • RAB6A/RAB6B is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers
  • RAB6A, RAB8A, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers
  • is involved in the trafficking of vesicles at the level of Golgi via interactions with numerous effector proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text non specific vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6KIFL
  • NSF
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi
  • RAB33B and RAB6A act to coordinate a major intra-Golgi retrograde trafficking pathway
  • DENND5A/DENND5B interacting with RAB6A/RAB6B
  • KIF1C transports RAB6A-vesicles and can influence Golgi complex organization
  • RAB6A binding to KIF1C motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C cellular functions
  • cell & other
    REGULATION
    activated by NSF (activation of ATPase activity)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS