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FLASH GENE
Symbol RAB6A contributors: mct/shn/pgu - updated : 20-09-2015
HGNC name RAB6A, member RAS oncogene family
HGNC id 9786
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus    
Nervousbrain    
Respiratoryrespiratory tractlarynx   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • binding domains of three RAB6A effector proteins: GOPC, BICD2, and DCTN1
  • HOMOLOGY
    interspecies homolog to murine Rab 6
    Homologene
    FAMILY
  • Rab6 family
  • CATEGORY protooncogene , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • regulates retrograde membrane traffic from endosomes to the Golgi apparatus and from the Golgi to the endoplasmic reticulum (ER)
  • regulates vesicle trafficking at the level of Golgi via recruitment of numerous and unrelated effectors
  • key regulator in the retrograde transfer from endosomes via the Golgi to the ER
  • regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT1 and COG
  • implicated in dynein-mediated vesicle movement at the Golgi apparatus and interact with a plethora of effector proteins
  • RAB1A and RAB6A may be involved in the regulation of the retinal adaptation
  • RAB33B/RAB6A regulated intra-Golgi retrograde trafficking pathway must coexist with other Golgi trafficking pathways
  • important role during neuritogenesis
  • RAB6A/RAB6B is a conserved small GTPase that localizes to the Golgi apparatus and cytoplasmic vesicles and controls transport and fusion of secretory carriers
  • RAB6A, RAB8A, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers
  • is involved in the trafficking of vesicles at the level of Golgi via interactions with numerous effector proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text non specific vesicle transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAB6KIFL
  • NSF
  • DYNLRB1 specifically interacts with all three RAB6 isoforms and co-localises at the Golgi
  • RAB33B and RAB6A act to coordinate a major intra-Golgi retrograde trafficking pathway
  • DENND5A/DENND5B interacting with RAB6A/RAB6B
  • KIF1C transports RAB6A-vesicles and can influence Golgi complex organization
  • RAB6A binding to KIF1C motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C cellular functions
  • cell & other
    REGULATION
    activated by NSF (activation of ATPase activity)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    age-down regulated in the frontal cortex
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS