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FLASH GENE
Symbol PTPRG contributors: mct/npt/pgu - updated : 05-05-2010
HGNC name protein tyrosine phosphatase, receptor type, G
HGNC id 9671
Location 3p14.2      Physical location : 61.547.242 - 62.280.572
Synonym name
  • DNA segment,single copy,probe LIB4-84
  • protein tyrosine phosphatase gamma
  • protein tyrosine phosphatase, receptor type, gamma polypeptide
  • Synonym symbol(s) D3S1249, PTPG, RPTPG, H_RG317H01.1, R-PTP-GAMMA, HPTPG
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 733.33 kb     30 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    Map cen - D3S1401 - D3S1397 - PTPRG - D3S1394 - D3S1400 - D3S1285 - D3S1403 - D3S1404 - D3S1217 - D3S1392 - D3S1395 - D3S1393 - D3S1261 - D3S1398 - D3S1399 - D3S1389 - D3S1296 - D3S1566 - D3S1562 - D3S6 - D3S1405 - qter
    Text see RCA1
    Physical map
    ABHD6 3p21.2 abhydrolase domain containing 6 RPP14 3p21.2 ribonuclease P (14kD) PXK 3p21.2 PX domain containing serine/threonine kinase PDHB 3p21.1-p14.3 pyruvate dehydrogenase (lipoamide) beta KCTD6 3p21.2 potassium channel tetramerisation domain containing 6 ACOX2 3p14.3 acyl-Coenzyme A oxidase 2, branched chain TU3A 3p21.1 Homo sapiens TU3A protein (TU3A), mRNA. LOC389126 3 LOC389126 FAM3D 3p21.1 family with sequence similarity 3, member D FLJ42117 3p21.2 FLJ42117 protein LOC339902 3p21.2 hypothetical LOC339902 NPCR 3p21.1 nasopharyngeal carcinoma-related protein LOC131691 3p21.1 similar to peptidyl-Pro cis trans isomerase LOC391540 3 similar to coated vesicle membrane protein LOC391541 3 similar to peptidyl-Pro cis trans isomerase PTPRG 3p14.2 protein tyrosine phosphatase, receptor type, G HT021 3p21.1 HT021 FEZL 3p21.1 likely ortholog of mouse and zebrafish forebrain embryonic zinc finger-like CADPS 3p21.1-p14.3 Ca2+-dependent activator protein for secretion LOC389127 3 similar to 40S ribosomal protein S10 LOC132205 3p21.1 similar to keratin 8, type II cytoskeletal - human SYNPR 3p14.3 synaptoporin LOC132203 3p21.1 similar to hypothetical protein A430083B19 LOC391542 3 similar to hypothetical protein FLJ23834 LOC132200 3p21.1 hypothetical protein BC015210 NIF3L1BP1 3p21.1 Ngg1 interacting factor 3 like 1 binding protein 1 SCA7 3p13-p12 spinocerebellar ataxia 7 (olivopontocerebellar atrophy with retinal degeneration) p44S10 3p21.1 proteasome regulatory particle subunit p44S10 PRICKLE2 3p21.1 prickle-like 2 (Drosophila) ADAMTS9 3p14.3-p14.2 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    30 - 6648 - 1445 - 1993 8382771
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunemacrophage
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • extracellular domain with a stretch of 266 AAs with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), and that may have a function other than catalysis of hydration of metabolic CO2
  • carbonic anhydrase-like domain interacting directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules
  • a carbonic anhydrase-like domain interacting directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules
  • HOMOLOGY
    Homologene
    FAMILY
  • protein tyrosine phosphatase (PTP) family
  • CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having critical interactions of PTPRG in the extracellular matrix milieu, inducing cell arrest and changes in cell cycle status
  • finely regulated protein in dendritic cells and macrophage subsets
  • PTPRG, PTPRZ1 and CNTNs are a group of receptors and ligands involved in the manifold recognition events that underlie the construction of neural networks
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CNTN3, 4, 5, and 6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the majority of high-grade astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC)
    Marker
    Therapy target
    ANIMAL & CELL MODELS