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FLASH GENE
Symbol PTPRG contributors: mct/npt/pgu - updated : 05-05-2010
HGNC name protein tyrosine phosphatase, receptor type, G
HGNC id 9671
DNA
TYPE functioning gene
STRUCTURE 733.33 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map cen - D3S1401 - D3S1397 - PTPRG - D3S1394 - D3S1400 - D3S1285 - D3S1403 - D3S1404 - D3S1217 - D3S1392 - D3S1395 - D3S1393 - D3S1261 - D3S1398 - D3S1399 - D3S1389 - D3S1296 - D3S1566 - D3S1562 - D3S6 - D3S1405 - qter
Text see RCA1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
30 - 6648 - 1445 - 1993 8382771
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/Immunemacrophage
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domain with a stretch of 266 AAs with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), and that may have a function other than catalysis of hydration of metabolic CO2
  • carbonic anhydrase-like domain interacting directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules
  • a carbonic anhydrase-like domain interacting directly with the second and third immunoglobulin repeats of the members of the contactin (CNTN) family of neural recognition molecules
  • HOMOLOGY
    Homologene
    FAMILY
  • protein tyrosine phosphatase (PTP) family
  • CATEGORY signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having critical interactions of PTPRG in the extracellular matrix milieu, inducing cell arrest and changes in cell cycle status
  • finely regulated protein in dendritic cells and macrophage subsets
  • PTPRG, PTPRZ1 and CNTNs are a group of receptors and ligands involved in the manifold recognition events that underlie the construction of neural networks
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CNTN3, 4, 5, and 6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in the majority of high-grade astrocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC)
    Marker
    Therapy target
    ANIMAL & CELL MODELS