Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

PTPRF

contributors: mct - updated : 11-04-2022

HGNC name	protein tyrosine phosphatase, receptor type, F
HGNC id	9670

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	BNAH2 breasts and/or nipples, aplasia or hypoplasia of, 2
Location	1p34.2      Physical location : 43.996.546 - 44.089.342
Synonym name	leukocyte antigen-related tyrosine phosphatase
	protein tyrosine phosphatase, receptor type, F polypeptide
Synonym symbol(s)	LAR, FLJ43335, FLJ45062, FLJ45567, BNAH2
EC.number	3.1.3.48

DNA

TYPE	functioning gene
STRUCTURE	101.62 kb     33 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001329138 37 - 6911 NP_001316067 - 1637 - 2019 31799666 NM_130440 33 - 7693 NP_569707 - 1898 - 2019 31799666 NM_001329140 31 - 6808 NP_001316069 - 1603 - 2019 31799666 NM_001329139 33 - 6868 NP_001316068 - 1623 - 2019 31799666 NM_002840 34 - 7720 NM_001329137 35 - 6887 NP_001316066 - 1629 - 2019 31799666

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver           mouth tongue     highly   pharynx       highly Endocrine pancreas         Nervous brain         Reproductive male system prostate       Respiratory respiratory tract larynx     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	fetal eyes, lens, eye anterior segment, optic nerve, retina, Retina Foveal and Macular, RPE and Choroid

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight fibronectin type III domains
	three immunoglobulin-like C2-type domains
	two protein-tyrosine phosphatase domains

HOMOLOGY

Homologene

FAMILY

LAR-RPTP subfamily

CATEGORY

adhesion , enzyme , tumor suppressor , receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane,junction,adherens
text	localizes to adherens junctions

basic FUNCTION	tyrosine phosphatase, receptor involved in axon guidance and mammary gland development
	possible cell adhesion receptor possessing an intrinsic protein tyrosine phosphatase activity
	receptor-type protein phosphatase that may be involved in the regulation of epithelial cell-cell contacts, peptide growth factor signaling, and the canonical Wnt pathway
	key role for PTPRF in the development of the nipple-areola region
	FAT2 and the receptor tyrosine phosphatase PTPRF function in a planar signaling system that coordinates leading and trailing edge dynamics between neighboring cells
	important phosphatase playing roles in regulating cell growth, differentiation and oncogenic transformation
	PTPRS, PTPRD, PTPRF participate in several brain functions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	DEPDC1B functions as an inhibitor of a RHOA-based signaling complex, which assembles on the PTPRF and mediates the integrity of focal adhesions (FAs)
	new role for PTPRF in regulating CDK1 activity and hence cell adhesion to the extracellular matrix
	role of PTPRF in mitotic retraction fiber integrity

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

BNAH2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in colorectal tumor tumoral     --low   in gastric adenocarcinomas, which was significantly associated with advanced tumor TNM stages

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach overexpressing PTPRF can significantly inhibit tumor migration and invasion

ANIMAL & CELL MODELS

half of the mouse embryos lacking both Ptprs and Ptprf (LAR) exhibit micrognathia (small lower jaw), cleft palate and microglossia/glossoptosis (small and deep tongue), a phenotype closely resembling Pierre-Robin