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FLASH GENE
Symbol PTPRF contributors: - updated : 24-06-2006
HGNC name protein tyrosine phosphatase, receptor type, F
HGNC id 9670
Location 1p34      Physical location : 43.996.546 - 44.089.342
Synonym name
  • leukocyte antigen-related tyrosine phosphatase
  • protein tyrosine phosphatase, receptor type, F polypeptide
  • Synonym symbol(s) LAR, FLJ43335, FLJ45062, FLJ45567
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 92.00 kb     33 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     mouthtongue  highly
     pharynx   highly
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratoryrespiratory tractlarynx  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text fetal eyes, lens, eye anterior segment, optic nerve, retina, Retina Foveal and Macular, RPE and Choroid
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight fibronectin type III domains
  • three immunoglobulin-like C2-type domains
  • two protein-tyrosine phosphatase domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adhesion , enzyme , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • tyrosine phosphatase, receptor involved in axon guidance and mammary gland development
  • possible cell adhesion receptor possessing an intrinsic protein tyrosine phosphatase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS