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FLASH GENE
Symbol PTPRF contributors: mct - updated : 11-04-2022
HGNC name protein tyrosine phosphatase, receptor type, F
HGNC id 9670
DNA
TYPE functioning gene
STRUCTURE 101.62 kb     33 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
37 - 6911 - 1637 - 2019 31799666
33 - 7693 - 1898 - 2019 31799666
31 - 6808 - 1603 - 2019 31799666
33 - 6868 - 1623 - 2019 31799666
34 - 7720
35 - 6887 - 1629 - 2019 31799666
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 mouthtongue  highly
 pharynx   highly
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text fetal eyes, lens, eye anterior segment, optic nerve, retina, Retina Foveal and Macular, RPE and Choroid
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight fibronectin type III domains
  • three immunoglobulin-like C2-type domains
  • two protein-tyrosine phosphatase domains
  • HOMOLOGY
    Homologene
    FAMILY LAR-RPTP subfamily
    CATEGORY adhesion , enzyme , tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    text
  • localizes to adherens junctions
  • basic FUNCTION
  • tyrosine phosphatase, receptor involved in axon guidance and mammary gland development
  • possible cell adhesion receptor possessing an intrinsic protein tyrosine phosphatase activity
  • receptor-type protein phosphatase that may be involved in the regulation of epithelial cell-cell contacts, peptide growth factor signaling, and the canonical Wnt pathway
  • key role for PTPRF in the development of the nipple-areola region
  • FAT2 and the receptor tyrosine phosphatase PTPRF function in a planar signaling system that coordinates leading and trailing edge dynamics between neighboring cells
  • important phosphatase playing roles in regulating cell growth, differentiation and oncogenic transformation
  • PTPRS, PTPRD, PTPRF participate in several brain functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DEPDC1B functions as an inhibitor of a RHOA-based signaling complex, which assembles on the PTPRF and mediates the integrity of focal adhesions (FAs)
  • new role for PTPRF in regulating CDK1 activity and hence cell adhesion to the extracellular matrix
  • role of PTPRF in mitotic retraction fiber integrity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BNAH2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in colorectal tumor
    tumoral     --low  
    in gastric adenocarcinomas, which was significantly associated with advanced tumor TNM stages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    overexpressing PTPRF can significantly inhibit tumor migration and invasion
    ANIMAL & CELL MODELS
  • half of the mouse embryos lacking both Ptprs and Ptprf (LAR) exhibit micrognathia (small lower jaw), cleft palate and microglossia/glossoptosis (small and deep tongue), a phenotype closely resembling Pierre-Robin