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FLASH GENE
Symbol PTGDR contributors: mct - updated : 20-02-2012
HGNC name prostaglandin D2 receptor (DP)
HGNC id 9591
Location 14q22.1      Physical location : 52.734.430 - 52.743.441
Synonym name
  • prostanoid DP receptor
  • PGD receptor
    • Synonym symbol(s) DP, AS1, DP1, ASRT1, MGC49004
    DNA
    TYPE functioning gene
    STRUCTURE 9.01 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2966 40.1 359 - 1995 7642548
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   lowly
     liver   lowly
    Nervousbrain   lowly
    Reproductivefemale systemuterus  lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ptgdr (74.1 pc)
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • multi-pass membrane protein
    • basic FUNCTION
  • acting as a receptor for prostaglandin D2 (PGD2)
  • being also a thromboxane receptor
  • in addition to PTDGR2, PTDGR plays an important role in eosinophil trafficking, and comediate with PTGDR2 the mobilization of eosinophils from bone marrow and their chemotaxis, which might provide the rationale for D-type prostanoid antagonists in the treatment of allergic disease
  • PTGDR and PTGDR2, act in concert to promote a number of biological effects associated with the development and maintenance of the allergic response
  • may have suppressive effects in controlling MUC5B overproduction in the airway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • male sex determination
    • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • prostaglandin D2 induces HMOX1 mRNA expression through the PTGDR
  • balance between PTGDR and PTGDR2 could influence the degree of PGD2-induced eosinophil migration and PTGDR agonist might regulate eosinophil activation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma-related traits type 1 (ASRT1)
    Variant & Polymorphism SNP
  • -613C > T PTGDR polymorphism protecting against asthma
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS