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FLASH GENE
Symbol PTGDR contributors: mct - updated : 20-02-2012
HGNC name prostaglandin D2 receptor (DP)
HGNC id 9591
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   lowly
 liver   lowly
Nervousbrain   lowly
Reproductivefemale systemuterus  lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Ptgdr (74.1 pc)
Homologene
FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text
  • multi-pass membrane protein
  • basic FUNCTION
  • acting as a receptor for prostaglandin D2 (PGD2)
  • being also a thromboxane receptor
  • in addition to PTDGR2, PTDGR plays an important role in eosinophil trafficking, and comediate with PTGDR2 the mobilization of eosinophils from bone marrow and their chemotaxis, which might provide the rationale for D-type prostanoid antagonists in the treatment of allergic disease
  • PTGDR and PTGDR2, act in concert to promote a number of biological effects associated with the development and maintenance of the allergic response
  • may have suppressive effects in controlling MUC5B overproduction in the airway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text
  • male sex determination
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • prostaglandin D2 induces HMOX1 mRNA expression through the PTGDR
  • balance between PTGDR and PTGDR2 could influence the degree of PGD2-induced eosinophil migration and PTGDR agonist might regulate eosinophil activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma-related traits type 1 (ASRT1)
    Variant & Polymorphism SNP
  • -613C > T PTGDR polymorphism protecting against asthma
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS