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FLASH GENE
Symbol PRR5L contributors: mct - updated : 09-05-2012
HGNC name proline rich 5 like
HGNC id 25878
Location 11p12      Physical location : 36.317.724 - 36.486.753
Synonym name
  • Protein observed with Rictor-2
    • Synonym symbol(s) FLJ14213, FLJ22630, MGC16218, PROTOR2
    DNA
    TYPE functioning gene
    STRUCTURE 169.03 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3979 - 368 - 2012 21964062
    10 - 3965 - 368 - 2012 21964062
    6 - 3378 - 240 - 2012 21964062
    7 - 3588 - 205 - 2012 21964062
    EXPRESSION
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • AKT1S1 and PRR5L are novel MTOR-associated proteins that control the balance between cell growth and cell death
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds specifically to CTRC2, via Rictor and/or SIN1
  • associates with ZFP36 to accelerate ZFP36-mediated mRNA turnover and functionally links the control of ZFP36-regulated mRNA stability to MTORC2 activity (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS