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FLASH GENE
Symbol PROK1 contributors: mct/npt - updated : 08-03-2010
HGNC name prokineticin 1
HGNC id 18454
Location 1p13.3      Physical location : 110.993.787 - 110.999.974
Synonym name
  • mambakine
  • black mamba toxin-related protein
  • endocrine-gland-derived vascular endothelial growth factor
  • Synonym symbol(s) PK1, PRK1, EGVEGF
    DNA
    TYPE functioning gene
    STRUCTURE 6.19 kb     3 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GPR61 1p13.1 G protein-coupled receptor 61 GNAI3 1p13 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 GNAT2 1p13 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 AMPD2 1p21-p13 adenosine monophosphate deaminase 2 (isoform L) GSTM4 1p13.3 glutathione S-transferase M4 GSTM2 1p13.3 glutathione S-transferase M2 (muscle) GSTM1 1p13.3 glutathione S-transferase M1 GSTM5 1p13.3 glutathione S-transferase M5 GSTM3 1p13.3 glutathione S-transferase M3 (brain) EPS8L3 1p13.2-p11 EPS8-like 3 CSF1 1p21-p13.3 colony stimulating factor 1 (macrophage) AHCYL1 1p12 S-adenosylhomocysteine hydrolase-like 1 PRO0233 1p13.2 PRO0233 protein ALX3 1p23-p21 aristaless-like homeobox 3 LOC164153 1p13.2 similar to RIKEN cDNA 4930522D07 LOC388661 1 LOC388661 LOC388662 1 similar to Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4 KCNC4 1p21 potassium voltage-gated channel, Shaw-related subfamily, member 4 LOC388663 1 LOC388663 RBM15 1p13 RNA binding motif protein 15 SLC16A4 1p13.1 solute carrier family 16 (monocarboxylic acid transporters), member 4 HBXIP 1p13.1 hepatitis B virus x interacting protein PROK1 1p21 prokineticin 1 LOC388664 1 similar to prochymosin KCNA10 1p13.1 potassium voltage-gated channel, shaker-related subfamily, member 10 KCNA2 1p13 potassium voltage-gated channel, shaker-related subfamily, member 2 KCNA3 1p13.3 potassium voltage-gated channel, shaker-related subfamily, member 3 LOC137829 1p13.2 similar to Nuclear receptor binding factor-2 CD53 1p13 CD53 antigen RIF1 1p13.2 receptor-interacting factor 1 MGC54289 1p13.2 hypothetical protein MGC54289 CEPT1 1p12 choline/ethanolaminephosphotransferase FLJ22457 1p13.2 hypothetical protein FLJ22457
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1372 - 105 - Li (2001)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     pancreas    
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivefemale systemplacenta   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta, expressed in the receptive endometrium and during early pregnancy (Evans 2009)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • AVIT (prokineticin) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • inducing proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands
  • potent angiogenic factor that bind to two G protein-coupled receptors to initiate its biological effects (Urayama 2007)
  • functions including tissue-specific angiogenesis, modulation of inflammatory responses, and regulation of hematopoiesis (Evans 2008)
  • enhances adhesion of trophoblast cells to fibronectin and laminin matrices, which are mediated predominantly via LIF induction, and mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor (Evans 2009)
  • highly specific mitogen which regulates proliferation and differentiation of the vascular endothelium (Morales 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    PROK1-PROKR1 signalling pathway regulating IL11
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PROK1-PROKR1 interaction induced inositol phosphate mobilization and sequential phosphorylation of c-Src, epidermal growth factor receptor, and ERK 1/2 (Evans 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS