basic FUNCTION
| vitamin K-dependent serine protease regulating blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids |
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negative regulation of apoptosis and blood coagulation |
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has an important role in governing intestinal microvascular inflammation |
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may protect macro and microcirculation from endotoxic shock |
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inhibits LPS-stimulated complement factor B promoter activity and protein expression, and thus have beneficial effect in therapy in sepsis |
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attenuating both hepatic and renal injury caused by hepatic ischemia and reperfusion injury |
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procoagulant role of PROC pathway may have important implications for the regulation of F3- and TFPI-dependent biologic responses and for fine tuning of the hemostatic balance in the vascular system |
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vitamin K-dependent serine protease zymogen in plasma which upon activation to activated protein C (PROC) by thrombin down-regulates the clotting cascade by limited proteolysis of the procoagulant cofactors Va and VIIIa |
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cytoprotective anticoagulant that can promote cutaneous healing |
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may influence bone cells and has potential to be a therapeutic drug for bone regeneration |