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FLASH GENE
Symbol PROC contributors: mct/pgu - updated : 09-09-2014
HGNC name protein C (inactivator of coagulation factors Va and VIIIa)
HGNC id 9451
ASSOCIATED DISORDERS
corresponding disease(s) PROC
related resource Database of Mutations Protein C
Susceptibility
  • to meningococcal disease in young children
  • to variation of bone mineral density in Caucasian men and women
  • Variant & Polymorphism other
  • promoter genotype might significantly influence susceptibility for meningococcal disease in young children
  • CNV significantly associated with bone mineral density in Caucasian men and women
  • Candidate gene
  • PROC pathway is defective in patients with inflammatory Bowel disease
  • Marker
  • decreased PROC levels in patients with type 2 diabetes may serve as a biomarker to indicate the early development of diabetic nephropathy
  • Therapy target
    SystemTypeDisorderPubmed
    bloodcoagulation 
    Zn2+ supports a physiological role in the regulation of anticoagulant activity of PROC and for treatments of thrombotic diseases
    ANIMAL & CELL MODELS