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FLASH GENE
Symbol PRKG1 contributors: mct - updated : 09-05-2014
HGNC name protein kinase, cGMP-dependent, type I
HGNC id 9414
Corresponding disease
TAAD6 thoracic aortic aneurysm with aortic dissection 6
Location 10q21.1      Physical location : 52.750.944 - 54.055.274
Synonym name
  • cGMP-dependent, regulatory, type I, beta
    • Synonym symbol(s) PRKGR1, PKG1, PGK, CGKI, PRKG1B, PKG, DKFZp686K042, FLJ36117, MGC71944, cGK-I
    EC.number 2.7.1.37
    DNA
    TYPE functioning gene
    STRUCTURE 1304.33 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    FLJ31737 LOC170370 10q11.23 hypothetical LOC170370 LOC170371 10q11.23 hypothetical protein LOC170371 LOC118461 DRG11 ERCC6 10q11 excision repair cross-complementing rodent repair deficiency, complementation group 6 PGBD3 10q11 piggyBac transposable element derived 3 CHAT 10q11.2 choline acetyltransferase SLC18A3 10q11.2 solute carrier family 18 (vesicular acetylcholine), member 3 LOC282966 10q11.23 hypothetical protein LOC282966 FLJ10851 10q11.23 hypothetical protein FLJ10851 MAPK6PS6 10q11.21 hypothetical protein FLJ10851 PARG 10q11.23 poly (ADP-ribose) glycohydrolase LOC387676 10 similar to KIAA0592 protein LOC387677 10 hypothetical gene supported by BC051717; NM_133446 LOC255319 10q11.23 similar to ARF GTPase-activating protein MSMB 10q11.2 microseminoprotein, beta- NCOA4 10q11.2 nuclear receptor coactivator 4 TIMM23 10q11.21-q11.23 translocase of inner mitochondrial membrane 23 homolog (yeast) LOC387678 10 similar to ARF GTPase-activating protein LOC389965 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC387679 10 similar to KIAA0592 protein LOC387680 10 similar to KIAA0592 protein LOC389966 10 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) ASAH2 10q11.21 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 LOC387681 10 hypothetical gene supported by BT007130; NM_001378 MOB 10q11.2 mob protein LOC340858 10q21.1 similar to hypothetical protein FLJ10539 FLJ31958 10q21.1 hypothetical protein FLJ31958 LOC389967 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC389968 10 similar to Cathepsin L preproprotein LOC283023 10q21.1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) ACF 10q21,1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) PRKG1 10q11.2 protein kinase, cGMP-dependent, type I CSTF2T 10q22-q23 protein kinase, cGMP-dependent, type I DKK1 10q11.2 dickkopf homolog 1 (Xenopus laevis) LOC389969 10 similar to ribosomal protein L31 LOC387682 10 similar to 52 kDa repressor of the inhibitor of the protein kinase (p58IPK-interacting protein) (58 kDa interferon-induced protein kinase-interacting protein) (P52rIPK) (Death associated protein 4) (THAP domain protein 0) MBL2 10q11.2-q21 mannose-binding lectin (protein C) 2, soluble (opsonic defect)
    RNA
    TRANSCRIPTS type messenger
    text with two alternatively spliced isoforms,1 alpha,1 beta
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3824 - 671 predominantly, in lung and placenta, and in penile erectile tissue 2011 21526164
  • isoform alpha or 1alpha
    • 18 - 3792 - 686 bladder, uterus, adrenals, fallopian tube, and in penile erectile tissue 2011 21526164
  • isoform beta or 1beta
    		•
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinner    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumhair cell receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal leucine zipper domain mediating interactions with RGS2, and &
    • 8764;50 AAs of the kinase are required for homodimerization and association with isoform-specific PKG-anchoring proteins (GKAPs), which target the kinase to specific substrates
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY PRK family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • relaxing vascular smooth muscle and inhibiting platelet aggregation
  • significant role in the control of smooth muscle function in human penile erectile tissue
  • key regulator of cardiovascular physiology and pathology
  • its activity prevents pathological-level nitric oxide-induced apoptosis and promotes DNA synthesis/cell proliferation in vascular smooth muscle cells
  • key mediator of the nitric oxide/cGMP signaling pathway and plays a central role in regulating cardiovascular and neuronal functions
  • modulates glucagon release from pancreatic alpha-cells
  • serves as an integral component of second messenger signaling in a number of biological contexts including cell differentiation, memory, and vasodilation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • important behavioral and physiological functions for the GUCY2C/PRKG1 signaling pathway within the brain
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with RGS2
  • interacting with TP53 (TP53-dependent expression of PRKG1 is required for the ability of cGMP to counteract growth cone collapse)
  • exerts dual regulation of cardiac KCNJ channels
  • PRKG1 interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation
  • DAPK2 is likely one of the targets of PRKG1 in apoptosis induction
  • PRKG1 is a novel regulator of AR-mediated transcription by enhancing AR cofactor WDR77 function, which provide a novel mechanism for the growth regulation of prostate cancer cells by the androgen signaling
  • PRKG1 is a potent negative modulator of cardiac systolic mechanosignaling that requires TRPC6 as the target effector
    • cell & other
    REGULATION
    Other its expression is subjected to post-transcriptional regulation in vascular smooth muscle cells through the 3 prime UTR of its mRNA
    TP53 is a transcription factor that regulates the expression of PRKG1 during neuronal maturation and cGMP-dependent inhibition of growth cone collapse
    ASSOCIATED DISORDERS
    corresponding disease(s) TAAD6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in non-neuronal cells results in a complex metabolic phenotype, including liver inflammation and fasting hyperglycemia (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • greater vulnerability to Noise-induced hearing loss (NIHL) in mice with deletion of Prkg1 as compared to mice without the deletion