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FLASH GENE
Symbol PRKCH contributors: mct - updated : 15-03-2011
HGNC name protein kinase C, eta
HGNC id 9403
Location 14q23.1      Physical location : 61.788.514 - 62.017.695
Synonym symbol(s) PKCL, PRKCL, PKC-L, MGC26269, MGC5363
EC.number 2.7.1.37
DNA
TYPE functioning gene
STRUCTURE 229.18 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
Binding site   enhancer
text structure
  • 5' prime untranslated region is unusually long and GC rich, characteristic of many oncogenes and growth regulatory genes )
    • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3522 - 683 - 1999 10497222
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestivemouth   highly
     pharynx   highly
    Lymphoid/Immunethymus   highly
    Respiratorylung   highly
    Skin/Tegumentskin   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two zinc-dependent phorbol-ester and Dag binding C1 domain
  • a C1b domain sufficient for translocation to the nuclear envelope, and that could also confer protection against etoposide-induced cell death
  • one C2, a consensus ATP-binding site, a catalytic kinase
  • a conserved cysteine-rich domains
  • a PIF domain
  • a Golgi luminal domain is potentially the major functional domain
  • a protein kinase domain
    • HOMOLOGY
    interspecies homolog to C.elegans fs7f5.5
    Homologene
    FAMILY
  • serine/threonine kinase family, PKC subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    text
  • epithelial specific isoform, localized at the cytoplasm and ER/Golgi
  • translocation to the nuclear envelope, and its spatial regulation could be important for its cellular functions including effects on cell death
    • basic FUNCTION
  • calcium-independent and phospholipids-dependent protein kinase, mediating the transcription activation of the transglutaminase 1 (TGM1) gene
  • having cellular functions including effects on cell cycle control and involvement in tumor promotion, regulated by translocation to the nuclear envelope
  • mediates glioblastoma cell proliferation through the Akt and MTOR signaling pathways
  • regulates occludin phosphorylation and epithelial tight junction integrity
  • positively regulates agonist-induced thromboxane generation with no effects on platelet aggregation
  • confers protection against apoptosis induced by the DNA damaging agents, UVC irradiation and the anti-cancer drug--Camptothecin
  • anti-apoptotic protein, acting as a negative regulator of JNK activity
  • play important roles in cell proliferation, differentiation, apoptosis, migration and tumorigenesis
  • increased JUND in keratinocytes
  • with PRKCD, differently regulate the expression of loricrin and Jun family proteins in keratinocytes
  • is important for TLR2-mediated ABCA1 expression
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FEZ1
  • intercting with CEBPA and MAPK13 (can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA))
  • activation of PRKCH and PLD2 signaling pathway is an important mechanism for regulation of TLR2-induced ABCA1 expression
    • cell & other
    REGULATION
    activated by lipids
    induced by EFHD2 (PRKCB1/PRKCH-inducible gene that modulates mast cell activation through NF-kappaB-dependent pathway
    Other regulated at the translational level both under normal growth conditions and during stress imposed by amino acid starvation, the latter causing a marked increase in its protein levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma, and may represent a molecular lesion in the development of more aggressive form
    Susceptibility
  • to cerebral lacunar infarction
  • to rheumatoid arthritis
    • Variant & Polymorphism SNP
  • -rs3783799 and rs2230500 increasing the risk of cerebral silent lacunar infarction
  • could be associated with the patho-physiologic mechanism of rheumatoid arthritis
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    could represent a target for intervention aimed to reduce resistance to anti-cancer treatments
    ANIMAL & CELL MODELS