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FLASH GENE
Symbol PRKCH contributors: mct - updated : 15-03-2011
HGNC name protein kinase C, eta
HGNC id 9403
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestivemouth   highly
 pharynx   highly
Lymphoid/Immunethymus   highly
Respiratorylung   highly
Skin/Tegumentskin   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two zinc-dependent phorbol-ester and Dag binding C1 domain
  • a C1b domain sufficient for translocation to the nuclear envelope, and that could also confer protection against etoposide-induced cell death
  • one C2, a consensus ATP-binding site, a catalytic kinase
  • a conserved cysteine-rich domains
  • a PIF domain
  • a Golgi luminal domain is potentially the major functional domain
  • a protein kinase domain
  • HOMOLOGY
    interspecies homolog to C.elegans fs7f5.5
    Homologene
    FAMILY
  • serine/threonine kinase family, PKC subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    text
  • epithelial specific isoform, localized at the cytoplasm and ER/Golgi
  • translocation to the nuclear envelope, and its spatial regulation could be important for its cellular functions including effects on cell death
  • basic FUNCTION
  • calcium-independent and phospholipids-dependent protein kinase, mediating the transcription activation of the transglutaminase 1 (TGM1) gene
  • having cellular functions including effects on cell cycle control and involvement in tumor promotion, regulated by translocation to the nuclear envelope
  • mediates glioblastoma cell proliferation through the Akt and MTOR signaling pathways
  • regulates occludin phosphorylation and epithelial tight junction integrity
  • positively regulates agonist-induced thromboxane generation with no effects on platelet aggregation
  • confers protection against apoptosis induced by the DNA damaging agents, UVC irradiation and the anti-cancer drug--Camptothecin
  • anti-apoptotic protein, acting as a negative regulator of JNK activity
  • play important roles in cell proliferation, differentiation, apoptosis, migration and tumorigenesis
  • increased JUND in keratinocytes
  • with PRKCD, differently regulate the expression of loricrin and Jun family proteins in keratinocytes
  • is important for TLR2-mediated ABCA1 expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FEZ1
  • intercting with CEBPA and MAPK13 (can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA))
  • activation of PRKCH and PLD2 signaling pathway is an important mechanism for regulation of TLR2-induced ABCA1 expression
  • cell & other
    REGULATION
    activated by lipids
    induced by EFHD2 (PRKCB1/PRKCH-inducible gene that modulates mast cell activation through NF-kappaB-dependent pathway
    Other regulated at the translational level both under normal growth conditions and during stress imposed by amino acid starvation, the latter causing a marked increase in its protein levels
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hepatocellular carcinoma, and may represent a molecular lesion in the development of more aggressive form
    Susceptibility
  • to cerebral lacunar infarction
  • to rheumatoid arthritis
  • Variant & Polymorphism SNP
  • -rs3783799 and rs2230500 increasing the risk of cerebral silent lacunar infarction
  • could be associated with the patho-physiologic mechanism of rheumatoid arthritis
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    could represent a target for intervention aimed to reduce resistance to anti-cancer treatments
    ANIMAL & CELL MODELS