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FLASH GENE
Symbol PRKAR1B contributors: npt/ - updated : 31-08-2006
HGNC name protein kinase, cAMP-dependent, regulatory, type I, beta
HGNC id 9390
Location 7p22.3      Physical location : 588.833 - 767.313
Synonym symbol(s) KAP1, PRKAR1
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 162.75 kb     11 Exon(s)
MAPPING cloned Y linked Y status provisional
Map pter - PRKAR1B -(12/2)- D7S21 -(9/2)- D7S108 -(0/21)- D7S17 -(11/5)- D7S149 -(13/35)- D7S62 -(8/11)- D7S55 - cen
Authors Solberg (92)
Physical map
LOC392937 7 similar to RCC1-like G exchanging factor-like isoform 1; RCC1-like G exchanging factor-like LOC392763 7 similar to intestinal mucin LOC253289 7p22.3 similar to cAMP-dependent protein kinase type I-beta regulatory chain LOC389604 7 similar to vasoactive intestinal peptide receptor 2 LOC392727 7 similar to general transcription factor II, i isoform 1; BTK-associated protein, 135kD; Williams-Beuren syndrome chromosome region 6; Bruton tyrosine kinase-associated protein 135 LOC392165 7 similar to Platelet-derived growth factor, A chain precursor (PDGF A-chain) (Platelet-derived growth factor alpha polypeptide) (PDGF-1) LOC392611 7 similar to bA476I15.3 (novel protein similar to septin) LOC392764 7 similar to mucin 11 LOC392615 7 similar to cAMP-dependent protein kinase type I-beta regulatory chain LOC392612 7 LOC392612 LOC389453 7 similar to bA476I15.3 (novel protein similar to septin) LOC392938 7 similar to opposite strand transcription unit to Stag3; Gats protein LOC389605 7 hypothetical gene supported by BC018568 PDGFA 7p22 platelet-derived growth factor alpha polypeptide NCF1 7q11.23 neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1) LOC392166 7 similar to cAMP-dependent protein kinase type I-beta regulatory chain LOC389454 7 LOC389454 LOC392765 7 similar to intestinal membrane mucin MUC17 LOC392164 7 similar to cAMP-dependent protein kinase type I-beta regulatory chain LOC392163 7 similar to 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha PRKAR1B 7p22 protein kinase, cAMP-dependent, regulatory, type I, beta EN2 7q36.2 engrailed homolog 2 TRIM56 7q11.2 tripartite motif-containing 56 FLJ20397 7p22.3 hypothetical protein FLJ20397 PMS2L2 7q11-q22 postmeiotic segregation increased 2-like 2 LOC393075 7 similar to RIKEN cDNA 9630008K15 gene LOC392728 7 similar to Cohesin subunit SA-3 (Stromal antigen 3) (SCC3 homolog 3) SERPINE1 7q21.3-q22.1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 LOC392729 7 similar to PMS2L13 LOC392613 7 LOC392613 LOC389455 7 LOC389455 LOC392731 7 LOC392731 LOC392730 7 hypothetical gene supported by AK024602 AP1S1 7q11.22 adaptor-related protein complex 1, sigma 1 subunit UNC84A 7p22.3 unc-84 homolog A (C. elegans) VGF 7q22 VGF nerve growth factor inducible
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 2488 - 381 - -
- - 2423 - 381 - -
- - 2533 - 381 - -
- - 2554 - 381 - -
- - 2494 - 381 - -
10 - 2512 - 10 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Nervousbrain   highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two cyclic nucleotide-binding domains
  • mono polymer monomer , dimer
    isoforms Precursor inactive form of the enzyme is composed of two regulatory chains and two catalytic chains
    HOMOLOGY
    interspecies homolog to murine Prkar1b
    Homologene
    FAMILY
  • c-AMP-dependent kinase regulatory chain family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • two active catalytic monomers and a regulatory dimer that binds four c-AMP molecules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WRN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS