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FLASH GENE
Symbol PRKAR1B contributors: npt/ - updated : 31-08-2006
HGNC name protein kinase, cAMP-dependent, regulatory, type I, beta
HGNC id 9390
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Nervousbrain   highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two cyclic nucleotide-binding domains
  • mono polymer monomer , dimer
    isoforms Precursor inactive form of the enzyme is composed of two regulatory chains and two catalytic chains
    HOMOLOGY
    interspecies homolog to murine Prkar1b
    Homologene
    FAMILY
  • c-AMP-dependent kinase regulatory chain family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • two active catalytic monomers and a regulatory dimer that binds four c-AMP molecules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with WRN
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS