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FLASH GENE
Symbol PRG2 contributors: mct - updated : 23-09-2014
HGNC name proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
HGNC id 9362
Location 11q12.1      Physical location : 57.154.834 - 57.158.130
Synonym name
  • eosinophil granule major basic protein
  • bone-marrow proteoglycan
  • natural killer cell activator
  • Synonym symbol(s) BMPG, MBP, MGC14537, MBP1, MGC14537, proMBP
    DNA
    TYPE functioning gene
    STRUCTURE 3.30 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    Binding site
    text structure two alternative promoters P& and Pé
  • binding sites for CEBPE,GATA1,SPI1
  • MAPPING cloned Y linked N status provisional
    Physical map
    OR5G3P 11 olfactory receptor, family 5, subfamily G, member 3 pseudogene LOC390180 11 similar to putative delta 6-desaturase LOC219522 11q12.1 similar to Olfactory receptor 5AK3 LOC390181 11 similar to Olfactory receptor 5AK2 LOC390182 11 similar to Olfactory receptor 5AK2 LOC219525 11q12.1 olfactory-like receptor (PJCG3) pseudogene LOC219527 11q12.1 similar to expressed sequence AI841794 AGTRL1 11q12 angiotensin II receptor-like 1 TNKS1BP1 11q12.2 tankyrase 1 binding protein 1, 182kDa SSRP1 11q12.1-q12.2 structure specific recognition protein 1 P2RX3 11q12 purinergic receptor P2X, ligand-gated ion channel, 3 PRG3 11q12 proteoglycan 3 PRG2 11q12 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) EEG1 11q11 likely ortholog of mouse embryonic epithelial gene 1 NGRH1 SLC43A1 11p11.2-p11.1 solute carrier family 43, member 1 TIMM10 11q12.1-q12.3 translocase of inner mitochondrial membrane 10 homolog (yeast) LOC219537 11q12.1 similar to RIKEN cDNA 1110030K22 UBE2L6 11q12 ubiquitin-conjugating enzyme E2L 6 LOC390183 11 similar to ribosomal protein S4, X-linked SERPING1 11q12.1 serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) FLJ30213 11q12.1 hypothetical protein FLJ30213 HEAB 11q12 hypothetical protein FLJ30213 ZDHHC5 11q12.2 zinc finger, DHHC domain containing 5 LCMR1 11q12.1 lung cancer metastasis-related protein 1 TMX2 11cen-q22.3 thioredoxin-related transmembrane protein 2 SELH 11q12.1 selenoprotein H CTNND1 11q11 catenin (cadherin-associated protein), delta 1 LOC390184 11 similar to seven transmembrane helix receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 874 25.2 222 - Li (1995)
    - splicing 1630 25.2 222 higher in immature cells Li (1995)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • lectin C type domain, 15AA hydrophobic signal sequence
  • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • plasticity-related gene family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mediator of injury to parasites and tissues in allergy inflammation
  • brain-specific integral membrane protein implicated in neuronal plasticity, such as filopodia formation and axon growth after brain lesion (Broggini 2010)
  • phospholipid-interacting molecule, important for thalamocortical axon guidance
  • bioactive phospholipids and PRG2 are critical for guiding thalamic axons to their proper cortical targets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • detaches surface-bound PAPPA in a process that depends on the PRG2 GAG and also on the formation of intermolecular disulfide bonds between PAPPA and PRG2
  • RDX is a PRG2 interaction partner and radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG2
  • cell & other
    REGULATION
    Other synergistically transactivated by GATA1 and SPI (PU-1) in the cotext of optimal level of GATA1
    GATA1 PU1 synergy abolished and PRG2 repressed by CEBPespilon special isoform
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS