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Symbol PRG2 contributors: mct - updated : 23-09-2014
HGNC name proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
HGNC id 9362
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticeosinophil
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • lectin C type domain, 15AA hydrophobic signal sequence
    • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • plasticity-related gene family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mediator of injury to parasites and tissues in allergy inflammation
  • brain-specific integral membrane protein implicated in neuronal plasticity, such as filopodia formation and axon growth after brain lesion (Broggini 2010)
  • phospholipid-interacting molecule, important for thalamocortical axon guidance
  • bioactive phospholipids and PRG2 are critical for guiding thalamic axons to their proper cortical targets
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • detaches surface-bound PAPPA in a process that depends on the PRG2 GAG and also on the formation of intermolecular disulfide bonds between PAPPA and PRG2
  • RDX is a PRG2 interaction partner and radixin accumulation in growth cones and its LPA-dependent phosphorylation depend on its binding to specific regions within the C-terminal region of PRG2
    • cell & other
    REGULATION
    Other synergistically transactivated by GATA1 and SPI (PU-1) in the cotext of optimal level of GATA1
    GATA1 PU1 synergy abolished and PRG2 repressed by CEBPespilon special isoform
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS