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FLASH GENE

Symbol

PRELID1

contributors: mct - updated : 06-07-2016

HGNC name	peroxisomal biogenesis factor 19
HGNC id	30255

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q35.3      Physical location : 176.730.834 - 176.733.949
Synonym name	25 kDa protein of relevant evolutionary and lymphoid interest
	px19-like protein
	PRELI domain-containing protein 1, mitochondrial
	protein of relevant evolutionary and lymphoid interest
Synonym symbol(s)	PRELI, CGI-106, MGC87972, SBBI12, PX19, CGI-106, PRELI, PX19, SBBI12

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	evolutionarily conserved MAD3/PRELI/RAB24 gene cluster
STRUCTURE	3.19 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013237 5 - 1287 NP_037369 25 219 - 2013 23931759 NM_001271828 5 - 1255 NP_001258757 - 208 - 2013 23931759

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly   liver       moderately   pancreas exocrine       moderately Reproductive female system uterus cervix   highly   female system breast mammary gland   moderately   female system ovary     moderately Skin/Tegument skin       highly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a stand-alone 170 amino acid PRELI/MSF1p' motif at its N-terminus, N-terminal mitochondrial signal domains
	a mitochondrial targeting signal
	a late embryogenesis abundant (LEA) motif
	C-terminal (A/TAEKAK) motif repeats

HOMOLOGY

interspecies

homolog to yeast Ups1p

Homologene

FAMILY

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,interspace
	intracellular,cytoplasm,organelle,membrane
	intracellular,nucleus,nucleoplasm

basic FUNCTION	may be important for the development of vital and immunocompetent organs
	induces oxidative stress and a mitochondrial apoptosis pathway in human primary Th cells
	is a novel factor influencing the human primary Th-cell death and differentiation
	is a vital LEA B cell protein with failsafe genetics
	is likely a crucial protein in the suppression of apoptosis in HepG2 cells in response to oxidative stress

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , immunity/defense

PATHWAY

metabolism

signaling

a component

complex of TRIAP1 (p53CSV) and PRELID1 in the mitochondrial intermembrane space (IMS), which ensures the accumulation of cardiolipin in mitochondria

INTERACTION

DNA

RNA

small molecule

protein	calpain, an oxidative stress-induced cysteine protease, is involved in the PRELID1-induced down-regulation of STAT6
	is a novel factor influencing the human primary Th-ce
	can associate with dynamin-like GTPase Optic Atrophy-1 (OPA1) and contribute to the maintenance of mitochondrial morphology
	TRIAP1/PRELID1 complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS