Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PRELID1 contributors: mct - updated : 06-07-2016
HGNC name peroxisomal biogenesis factor 19
HGNC id 30255
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a stand-alone 170 amino acid PRELI/MSF1p' motif at its N-terminus, N-terminal mitochondrial signal domains
  • a mitochondrial targeting signal
  • a late embryogenesis abundant (LEA) motif
  • C-terminal (A/TAEKAK) motif repeats
    • HOMOLOGY
    interspecies homolog to yeast Ups1p
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be important for the development of vital and immunocompetent organs
  • induces oxidative stress and a mitochondrial apoptosis pathway in human primary Th cells
  • is a novel factor influencing the human primary Th-cell death and differentiation
  • is a vital LEA B cell protein with failsafe genetics
  • is likely a crucial protein in the suppression of apoptosis in HepG2 cells in response to oxidative stress
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complex of TRIAP1 (p53CSV) and PRELID1 in the mitochondrial intermembrane space (IMS), which ensures the accumulation of cardiolipin in mitochondria
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • calpain, an oxidative stress-induced cysteine protease, is involved in the PRELID1-induced down-regulation of STAT6
  • is a novel factor influencing the human primary Th-ce
  • can associate with dynamin-like GTPase Optic Atrophy-1 (OPA1) and contribute to the maintenance of mitochondrial morphology
  • TRIAP1/PRELID1 complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS