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FLASH GENE
Symbol PRDM14 contributors: mct/npt - updated : 02-10-2018
HGNC name PR domain containing 14
HGNC id 14001
Location 8q13.3      Physical location : 70.964.024 - 70.983.562
Synonym name
  • PR-domain zinc finger protein 14
  • positive regulatory domain family protein 14
  • Synonym symbol(s) PFM11, MGC59730
    DNA
    TYPE functioning gene
    STRUCTURE 19.10 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ11267 8q13.1 hypothetical protein FLJ11267 PTTG3 8q13.1 hypothetical protein FLJ11267 SGKL 8q12.3-q13.1 serum/glucocorticoid regulated kinase-like FLJ25692 8q13.1 hypothetical protein FLJ25692 LOC392228 8 similar to hypothetical class II basic helix-loop-helix protein LOC286187 8q13.1 similar to RIKEN cDNA 1700011J18 COPS5 8q13.1 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) FLJ22490 8q13.1 hypothetical protein FLJ22490 BIG1 8q13 hypothetical protein FLJ22490 LOC389666 8 LOC389666 LOC392229 8 similar to 60S ribosomal protein L17 (L23) (Amino acid starvation-induced protein) (ASI) CPA6 8q12.3 carboxypeptidase A6 FLJ12987 8q13.1 hypothetical protein FLJ12987 VEST1 8q13 vestibule-1 protein LOC389667 8 similar to tropomyosin 4 SULF1 8q13.1 similar to tropomyosin 4 SLCO5A1 8q13.2 solute carrier family 21 (organic anion transporter), member 15 LOC392230 8 similar to BAG-family molecular chaperone regulator-4 (Silencer of death domains) PRDM14 8p21-p12 PR domain containing 14 LOC346990 8q13.2 similar to H2A histone family, member Z NCOA2 8q13.1 nuclear receptor coactivator 2 LOC392231 8 similar to basic transcription factor 3 TRAM1 8q13.1 translocation associated membrane protein 1 CGI-83 LOC389668 8 similar to hypothetical protein FLJ10307 EYA1 8q13.3 eyes absent homolog 1 (Drosophila) MSC 8q21.1-q21.2 musculin (activated B-cell factor-1) TRPA1 8q13 transient receptor potential cation channel, subfamily A, member 1 LOC392232 8 similar to ankyrin-like protein 1; ankyrin-like with transmembrane domains 1 KCNB2 8q13.2 potassium voltage-gated channel, Shab-related subfamily, member 2 TERF1 8q13 telomeric repeat binding factor (NIMA-interacting) 1 RPESP 8q13.3 RPE-spondin LOC392233 8 similar to Hspcb protein LOC389669 8 LOC389669 RPL7 8q12-q22 ribosomal protein L7 RDH10 8q13.3 retinol dehydrogenase 10 (all-trans)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2344 64.1 571 - 2018 29178343
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx    
    Reproductivefemale systemovary   
     male systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a PR domain (PRDI-BF1 and RIZ) related to the SET methyltransferase domain and zinc finger motifs
  • six zinc finger DNA binding motifs, C2H2 type
  • a subtype of the SET domain which catalyzes histone methylation
  • HOMOLOGY
    Homologene
    FAMILY
  • PR-domain protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the maintenance of the self-renewal of embryonis stem (ES) cells by suppression of gene expression
  • may be involved in epigenetic control of gene expression in undifferentiated ES cells
  • critical role for PRDM14 in programming PGCs and promoting pluripotency in ES cells
  • PRDM14, the PR domain-containing transcriptional regulator, accelerates the TET1, TET2- base excision repair (BER) cycle, resulting in the promotion of active DNA demethylation in ESCs
  • is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation
  • exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation
  • might have the histone methyltransferase activity, and suppress the differentiation marker genes via histone modifications
  • transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in some cancers
  • HSP90AA1 and HSPA5 interact with PRDM14 and participate in cancer regulation
  • HOXA1 displays an unexpectedly long half-life and PRDM14 can reduce the stability and affect the transcriptional activity of HOXA1
  • is a unique epigenetic regulator stabilizing transcriptional networks for pluripotency
  • maintains stemness in embryonic stem cells and primordial germ cells via epigenetic mechanisms
  • confers stem cell-like characteristics upon cancer cells, such as sphere formation, dye efflux, chemotherapy resistance, proliferation, and distant metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • regulates the proper splicing of transcripts encoding for pluripotency regulators such as POU5F1, PRDM14, E4F1 and MED24
  • maintains pluripotency of embryonic stem cells through TET1, TET2-mediated active DNA demethylation
  • its repressive function is mediated through an ETO-family co-repressor CBFA2T2, which tightly binds to the pre-SET/SET domains of PRDM14
  • PRDM14 is an interactor of HOXA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer (Nishikawa 2007)
    tumoral     --over  
    in pancreatic cancer tissues compared with normal pancreatic tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for predicting unfavorable prognosis in non-small cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential therapeutic molecular target for tumor treatment
    cancerendocrinepancreas
    targeting the overexpression of PRDM14 suppresses cancer stem-like phenotypes, including liver metastasis
    ANIMAL & CELL MODELS