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Symbol PRDM14 contributors: mct/npt - updated : 02-10-2018
HGNC name PR domain containing 14
HGNC id 14001
Location 8q13.3      Physical location : 70.964.024 - 70.983.562
Synonym name
  • PR-domain zinc finger protein 14
  • positive regulatory domain family protein 14
  • Synonym symbol(s) PFM11, MGC59730
    TYPE functioning gene
    STRUCTURE 19.10 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ11267 8q13.1 hypothetical protein FLJ11267 PTTG3 8q13.1 hypothetical protein FLJ11267 SGKL 8q12.3-q13.1 serum/glucocorticoid regulated kinase-like FLJ25692 8q13.1 hypothetical protein FLJ25692 LOC392228 8 similar to hypothetical class II basic helix-loop-helix protein LOC286187 8q13.1 similar to RIKEN cDNA 1700011J18 COPS5 8q13.1 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) FLJ22490 8q13.1 hypothetical protein FLJ22490 BIG1 8q13 hypothetical protein FLJ22490 LOC389666 8 LOC389666 LOC392229 8 similar to 60S ribosomal protein L17 (L23) (Amino acid starvation-induced protein) (ASI) CPA6 8q12.3 carboxypeptidase A6 FLJ12987 8q13.1 hypothetical protein FLJ12987 VEST1 8q13 vestibule-1 protein LOC389667 8 similar to tropomyosin 4 SULF1 8q13.1 similar to tropomyosin 4 SLCO5A1 8q13.2 solute carrier family 21 (organic anion transporter), member 15 LOC392230 8 similar to BAG-family molecular chaperone regulator-4 (Silencer of death domains) PRDM14 8p21-p12 PR domain containing 14 LOC346990 8q13.2 similar to H2A histone family, member Z NCOA2 8q13.1 nuclear receptor coactivator 2 LOC392231 8 similar to basic transcription factor 3 TRAM1 8q13.1 translocation associated membrane protein 1 CGI-83 LOC389668 8 similar to hypothetical protein FLJ10307 EYA1 8q13.3 eyes absent homolog 1 (Drosophila) MSC 8q21.1-q21.2 musculin (activated B-cell factor-1) TRPA1 8q13 transient receptor potential cation channel, subfamily A, member 1 LOC392232 8 similar to ankyrin-like protein 1; ankyrin-like with transmembrane domains 1 KCNB2 8q13.2 potassium voltage-gated channel, Shab-related subfamily, member 2 TERF1 8q13 telomeric repeat binding factor (NIMA-interacting) 1 RPESP 8q13.3 RPE-spondin LOC392233 8 similar to Hspcb protein LOC389669 8 LOC389669 RPL7 8q12-q22 ribosomal protein L7 RDH10 8q13.3 retinol dehydrogenase 10 (all-trans)
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2344 64.1 571 - 2018 29178343
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemovary   
     male systemtestis   
    cell lineage
    cell lines
    at STAGE
  • a PR domain (PRDI-BF1 and RIZ) related to the SET methyltransferase domain and zinc finger motifs
  • six zinc finger DNA binding motifs, C2H2 type
  • a subtype of the SET domain which catalyzes histone methylation
  • PR-domain protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • involved in the maintenance of the self-renewal of embryonis stem (ES) cells by suppression of gene expression
  • may be involved in epigenetic control of gene expression in undifferentiated ES cells
  • critical role for PRDM14 in programming PGCs and promoting pluripotency in ES cells
  • PRDM14, the PR domain-containing transcriptional regulator, accelerates the TET1, TET2- base excision repair (BER) cycle, resulting in the promotion of active DNA demethylation in ESCs
  • is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation
  • exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation
  • might have the histone methyltransferase activity, and suppress the differentiation marker genes via histone modifications
  • transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in some cancers
  • HSP90AA1 and HSPA5 interact with PRDM14 and participate in cancer regulation
  • HOXA1 displays an unexpectedly long half-life and PRDM14 can reduce the stability and affect the transcriptional activity of HOXA1
  • is a unique epigenetic regulator stabilizing transcriptional networks for pluripotency
  • maintains stemness in embryonic stem cells and primordial germ cells via epigenetic mechanisms
  • confers stem cell-like characteristics upon cancer cells, such as sphere formation, dye efflux, chemotherapy resistance, proliferation, and distant metastasis
    a component
    DNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • regulates the proper splicing of transcripts encoding for pluripotency regulators such as POU5F1, PRDM14, E4F1 and MED24
  • maintains pluripotency of embryonic stem cells through TET1, TET2-mediated active DNA demethylation
  • its repressive function is mediated through an ETO-family co-repressor CBFA2T2, which tightly binds to the pre-SET/SET domains of PRDM14
  • PRDM14 is an interactor of HOXA1
  • cell & other
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer (Nishikawa 2007)
    tumoral     --over  
    in pancreatic cancer tissues compared with normal pancreatic tissues
    Variant & Polymorphism
    Candidate gene
  • potential biomarker for predicting unfavorable prognosis in non-small cell lung cancer (NSCLC)
  • Therapy target
    may be a potential therapeutic molecular target for tumor treatment
    targeting the overexpression of PRDM14 suppresses cancer stem-like phenotypes, including liver metastasis