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FLASH GENE
Symbol PRDM14 contributors: mct/npt - updated : 02-10-2018
HGNC name PR domain containing 14
HGNC id 14001
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PR domain (PRDI-BF1 and RIZ) related to the SET methyltransferase domain and zinc finger motifs
  • six zinc finger DNA binding motifs, C2H2 type
  • a subtype of the SET domain which catalyzes histone methylation
  • HOMOLOGY
    Homologene
    FAMILY
  • PR-domain protein family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the maintenance of the self-renewal of embryonis stem (ES) cells by suppression of gene expression
  • may be involved in epigenetic control of gene expression in undifferentiated ES cells
  • critical role for PRDM14 in programming PGCs and promoting pluripotency in ES cells
  • PRDM14, the PR domain-containing transcriptional regulator, accelerates the TET1, TET2- base excision repair (BER) cycle, resulting in the promotion of active DNA demethylation in ESCs
  • is a sequence-specific transcriptional regulator of embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation
  • exerts its function, at least in part, through repressing genes associated with epigenetic modification and cell differentiation
  • might have the histone methyltransferase activity, and suppress the differentiation marker genes via histone modifications
  • transcriptional regulator that maintains pluripotency in embryonic stem cells, is overexpressed in some cancers
  • HSP90AA1 and HSPA5 interact with PRDM14 and participate in cancer regulation
  • HOXA1 displays an unexpectedly long half-life and PRDM14 can reduce the stability and affect the transcriptional activity of HOXA1
  • is a unique epigenetic regulator stabilizing transcriptional networks for pluripotency
  • maintains stemness in embryonic stem cells and primordial germ cells via epigenetic mechanisms
  • confers stem cell-like characteristics upon cancer cells, such as sphere formation, dye efflux, chemotherapy resistance, proliferation, and distant metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • regulates the proper splicing of transcripts encoding for pluripotency regulators such as POU5F1, PRDM14, E4F1 and MED24
  • maintains pluripotency of embryonic stem cells through TET1, TET2-mediated active DNA demethylation
  • its repressive function is mediated through an ETO-family co-repressor CBFA2T2, which tightly binds to the pre-SET/SET domains of PRDM14
  • PRDM14 is an interactor of HOXA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer (Nishikawa 2007)
    tumoral     --over  
    in pancreatic cancer tissues compared with normal pancreatic tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for predicting unfavorable prognosis in non-small cell lung cancer (NSCLC)
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may be a potential therapeutic molecular target for tumor treatment
    cancerendocrinepancreas
    targeting the overexpression of PRDM14 suppresses cancer stem-like phenotypes, including liver metastasis
    ANIMAL & CELL MODELS