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FLASH GENE
Symbol PRAF2 contributors: mct - updated : 01-12-2010
HGNC name PRA1 domain family, member 2
HGNC id 28911
Location Xp11.23      Physical location : 48.928.819 - 48.931.662
Synonym name
  • JM4 protein
  • Jena-Muenchen 4
    • Synonym symbol(s) JM4, FLJ57916
    DNA
    TYPE functioning gene
    STRUCTURE 2.85 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1263 19.3 178 - 2006 16481131
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Lymphoid/Immunespleen   highly Homo sapiens
    Nervousbrainlimbic systemhippocampus highly Homo sapiens
     brainhindbraincerebellum highly Homo sapiens
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Rab-acceptor motif, indicating a function in vesicle formation at the Golgi complex
  • four-transmembrane domains
    • HOMOLOGY
    interspecies ortholog to murine DXImx39e
    intraspecies homolog to JWA and glutamate transporter-associated protein 3-18 (GTRAP3-18)
    homolog to PRAF1, PRAF3
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text co-localises with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi
    basic FUNCTION
  • may function in trafficking and membrane localisation of the receptor, possibly also other receptors or amino acid transporters
  • plays a role in the regulation of intracellular protein transport
  • potential important physiological function by participating in multiple aspects of synaptic vesicles maturation, transport, and signal transmission
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • co-localise and heterodimerise with JWA, and GTRAP3-18
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CCR5
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer tissues of the breast, colon, lung, and ovary
    tumoral     --over  
    in malignant glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate prognostic marker of neuroblastoma
    Marker
    Therapy target
  • candidate molecular target for therapeutic intervention in gliomas
    • ANIMAL & CELL MODELS