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FLASH GENE
Symbol PRAF2 contributors: mct - updated : 01-12-2010
HGNC name PRA1 domain family, member 2
HGNC id 28911
DNA
TYPE functioning gene
STRUCTURE 2.85 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1263 19.3 178 - 2006 16481131
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Lymphoid/Immunespleen   highly Homo sapiens
Nervousbrainlimbic systemhippocampus highly Homo sapiens
 brainhindbraincerebellum highly Homo sapiens
Reproductivemale systemprostate  moderately
Respiratorylung   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Rab-acceptor motif, indicating a function in vesicle formation at the Golgi complex
  • four-transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine DXImx39e
    intraspecies homolog to JWA and glutamate transporter-associated protein 3-18 (GTRAP3-18)
    homolog to PRAF1, PRAF3
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text co-localises with calnexin in the endoplasmic reticulum and with the mannose 6-phosphate receptor in the Golgi
    basic FUNCTION
  • may function in trafficking and membrane localisation of the receptor, possibly also other receptors or amino acid transporters
  • plays a role in the regulation of intracellular protein transport
  • potential important physiological function by participating in multiple aspects of synaptic vesicles maturation, transport, and signal transmission
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • co-localise and heterodimerise with JWA, and GTRAP3-18
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with CCR5
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cancer tissues of the breast, colon, lung, and ovary
    tumoral     --over  
    in malignant glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene candidate prognostic marker of neuroblastoma
    Marker
    Therapy target
  • candidate molecular target for therapeutic intervention in gliomas
  • ANIMAL & CELL MODELS