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FLASH GENE
Symbol PPP2R2C contributors: - updated : 15-10-2005
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
HGNC id 9306
Location 4p16.1      Physical location : 6.322.305 - 6.474.326
Synonym symbol(s) PP2ABRG, PR52, IMYPNO, IMYPNO1
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 59.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D4S3038 - ADD1 - D4S412 - D4S2925 - MSX1 - PPP2R2C - D4S431 - D4S3007 - D4S394 - cen
Authors Torres (99) hu (00)
Physical map
MGC13159 4p16.2 hypothetical protein MGC13159 LYAR 4p16.2 hypothetical protein FLJ20425 ZNF509 4p16.2 zinc finger protein 509 D4S234E 4p16.3 DNA segment on chromosome 4 (unique) 234 expressed sequence STX18 4p16.2 syntaxin 18 MSX1 4p16.3-p16.1 msh homeo box homolog 1 (Drosophila) LDHAL1 4p16.3-p15.3 lactate dehydrogenase A-like 1 LOC132870 4p16.2 hypothetical gene LOC132870 C17 4p16-p15 hypothetical gene LOC132870 HSA250839 4p16.2 gene for serine/threonine protein kinase C4orf6 4p16 chromosome 4 open reading frame 6 EVC2 4p16.2-p16.1 Ellis van Creveld syndrome 2 (limbin) EVC 4p16 Ellis van Creveld syndrome CRMP1 4p16.1-p15 collapsin response mediator protein 1 LOC389197 4 hypothetical gene supported by BX648674 FLJ31564 LOC389198 4 LOC389198 WFS1 4p16.1 Wolfram syndrome 1 (wolframin) PPP2R2C 4p16.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform KIAA0935 4p16.1 protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform PGR1 4p16.1 T-cell activation protein LOC93622 4p16.1 hypothetical protein BC006130 S100P 4p16 S100 calcium binding protein P MGC9651 4p16.1 hypothetical protein MGC9651 CNO 4p16.1 cappuccino KIAA0232 4p16.1 KIAA0232 gene product KIAA1322 FLJ90575 4p16.1 hypothetical protein FLJ90575 MGC21874 4p16.1 transcriptional adaptor 2 (ADA2 homolog, yeast)-beta GRPEL1 4p16 GrpE-like 1, mitochondrial (E. coli) SORCS2 4p16 GrpE-like 1, mitochondrial (E. coli) AFAP 4p16 actin filament associated protein MGC10981 4p16.1 hypothetical protein MGC10981 LOC389199 4 hypothetical gene supported by BC031673 ABLIM2 4p16-p15 actin binding LIM protein 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - polyA site 4700 51.5 447 - H
U
- - polyA site 2200 - - brain and testis lowly Hu
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemprostate  lowly
 male systemtestis  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to C.elegans f26e4.1
intraspecies homolog to PPP2R2A,PPP2R2B
Homologene
FAMILY phosphatase 2a regulatory subunit b family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular compartment
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neuronal
    PATHWAY
    metabolism
    signaling
    a component regulatory subunit of protein phosphatase 2 A consisting of a common heterodimeric core enzyme, composed of a 36kDa catalytic subunit (subunit C) and a 65kDa constant regulatory subunit (pr65 or subunit A),and associating with a variety of regulatory subunits (including three families of subunits B)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS