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FLASH GENE

Symbol

PPP2R2C

contributors: - updated : 15-10-2005

HGNC name	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
HGNC id	9306

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4p16.1      Physical location : 6.322.305 - 6.474.326
Synonym symbol(s)	PP2ABRG, PR52, IMYPNO, IMYPNO1
EC.number	3.1.3.16

DNA

TYPE	functioning gene
STRUCTURE	59.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

Map	pter - D4S3038 - ADD1 - D4S412 - D4S2925 - MSX1 - PPP2R2C - D4S431 - D4S3007 - D4S394 - cen
Authors	Torres (99) hu (00)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - polyA site 4700 51.5 447 - H U - - polyA site 2200 - - brain and testis lowly Hu

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system prostate     lowly   male system testis     lowly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , trimer

HOMOLOGY

interspecies

homolog to C.elegans f26e4.1

intraspecies

homolog to PPP2R2A,PPP2R2B

Homologene

FAMILY

phosphatase 2a regulatory subunit b family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	modulating substrate selectivity and catalytic activity
	directing the localization of the catalytic enzyme to a particular compartment

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text

neuronal

PATHWAY

metabolism

signaling

a component

regulatory subunit of protein phosphatase 2 A consisting of a common heterodimeric core enzyme, composed of a 36kDa catalytic subunit (subunit C) and a 65kDa constant regulatory subunit (pr65 or subunit A),and associating with a variety of regulatory subunits (including three families of subunits B)

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS