Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP2R2C contributors: - updated : 15-10-2005
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
HGNC id 9306
Location 4p16.1      Physical location : 6.322.305 - 6.474.326
Synonym symbol(s) PP2ABRG, PR52, IMYPNO, IMYPNO1
EC.number 3.1.3.16
DNA
TYPE functioning gene
STRUCTURE 59.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map pter - D4S3038 - ADD1 - D4S412 - D4S2925 - MSX1 - PPP2R2C - D4S431 - D4S3007 - D4S394 - cen
Authors Torres (99) hu (00)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - polyA site 4700 51.5 447 - H
U
- - polyA site 2200 - - brain and testis lowly Hu
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivemale systemprostate  lowly
 male systemtestis  lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to C.elegans f26e4.1
intraspecies homolog to PPP2R2A,PPP2R2B
Homologene
FAMILY phosphatase 2a regulatory subunit b family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • modulating substrate selectivity and catalytic activity
  • directing the localization of the catalytic enzyme to a particular compartment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text neuronal
    PATHWAY
    metabolism
    signaling
    a component regulatory subunit of protein phosphatase 2 A consisting of a common heterodimeric core enzyme, composed of a 36kDa catalytic subunit (subunit C) and a 65kDa constant regulatory subunit (pr65 or subunit A),and associating with a variety of regulatory subunits (including three families of subunits B)
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS