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FLASH GENE
Symbol PPP2R1B contributors: mct/npt - updated : 01-09-2009
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
HGNC id 9303
Location 11q23.1      Physical location : 111.597.631 - 111.637.169
Synonym name
  • serine/threonine protein phosphatase 2A, 65 kDa regulatory
  • subunit A, beta isoform
  • PP2A-A-beta
  • protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform
  • PP2A, subunit A, R1-beta isoform
  • PP2A, subunit A, PR65-beta isoform
  • serine/threonine protein phosphatase 2A, 65 kDa regulatory
  • subunit A, beta isoform
    Synonym symbol(s) MGC26454, PR65B, PP2A-A-beta
    EC.number 3.1.3.16
    DNA
    TYPE functioning gene
    STRUCTURE 39.54 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D11S1343 - D11S2000 - D11S927 - D11S1647 - D11S1986 - PPP2R1B - D11S1347 - D11S4078 - D11S897 - D11S938 - qter
    Authors Baysal (98)
    Physical map
    MGC50104 11q23.2 Similar to RIKEN cDNA 1810046K07 gene LOC120376 11q23.2 hypothetical protein LOC120376 POU2AF1 11q23.1 POU domain, class 2, associating factor 1 BTG4 11q23.2-q23.3 B-cell translocation gene 4 LOC387807 11 hypothetical gene supported by AK128145; BC039505 LOC143903 11q23.2 layilin SIK2 11q23.2 salt-inducible serine/threonine kinase 2 PPP2R1B 11q23 protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform DIBD1 11q23 disrupted in bipolar affective disorder 1 C11orf1 11p15.5 chromosome 11 open reading frame 1 CRYAB 11q22.3-q23.1 crystallin, alpha B HSPB2 11q22.3-q23.1 heat shock 27kDa protein 2 MGC14839 11q23.2 similar to RIKEN cDNA 2310030G06 gene DIXDC1  DIX domain containing 1 LOC387808 11 similar to KIAA1735 protein DLAT 11q23.1 dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) LOC246731 11q23 peptidyl prolyl isomerase H (cyclophilin H) pseudogene LOC120379 11q23.2 hypothetical protein BC019238 FLJ10726 11q23.2 hypothetical protein FLJ10726 TIMM8B 11q23.1-q23.2 translocase of inner mitochondrial membrane 8 homolog B (yeast) SDHD 11q22.3-q23.1 succinate dehydrogenase complex, subunit D, integral membrane protein IL18 11q22.2-q22.3 interleukin 18 (interferon-gamma-inducing factor) TEX12 11q22 testis expressed sequence 12 BCDO2 11q22.3-q23.1 beta-carotene dioxygenase 2 MRPS36P4 11q23.2 mitochondrial ribosomal protein S36 pseudogene PTS 11q22.3-q23.3 6-pyruvoyltetrahydropterin synthase PLET1 11q23.2 placenta expressed transcript 1 LOC387809 11 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 polyA site 5605 66.2 601 - Baysal (1998)
  • large
  • D11S5020 in the 3'utr
  • 16 polyA site 2161 - 667 - Baysal (1998)
  • short
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus    
    Digestiveliver    
    Respiratorylung    
    Visualeyeretina   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Skin/Tegumentmelanocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 15 HEAT repeats, consisting of two alpha helices joined by a hydrophilic region
  • the intrarepeat loop (the repeat units may be arranged laterally to form a rod-like structure)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans F48E8.5
    intraspecies homolog to PPP2R1A
    Homologene
    FAMILY
  • phosphatase 2A regulatory subunit family
  • CATEGORY enzyme , tumor suppressor , receptor membrane kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine phosphatase implicated in the negative control of cell growth and division
  • tumor suppressor gene that transforms immortalized cells by regulating the function of RALA (Sablina 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric core enzyme, composed of a 36 kda catalytic subunit (subunit c) and a 65 kda constantregulatory subunit (pr65 or subunit a), that associates with a variety of regulatory subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation playing a role in the pathogenesis of B-cell chronic lymphocytic leukaemia (Kalla 2007)
    tumoral     --other  
    aberrant transcripts of might be associated with the development of hepatocellular carcinoma (Chou 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS