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FLASH GENE
Symbol PPP2R1B contributors: mct/npt - updated : 01-09-2009
HGNC name protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform
HGNC id 9303
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus    
Digestiveliver    
Respiratorylung    
Visualeyeretina   
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...)
Skin/Tegumentmelanocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15 HEAT repeats, consisting of two alpha helices joined by a hydrophilic region
  • the intrarepeat loop (the repeat units may be arranged laterally to form a rod-like structure)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans F48E8.5
    intraspecies homolog to PPP2R1A
    Homologene
    FAMILY
  • phosphatase 2A regulatory subunit family
  • CATEGORY enzyme , tumor suppressor , receptor membrane kinase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine phosphatase implicated in the negative control of cell growth and division
  • tumor suppressor gene that transforms immortalized cells by regulating the function of RALA (Sablina 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric core enzyme, composed of a 36 kda catalytic subunit (subunit c) and a 65 kda constantregulatory subunit (pr65 or subunit a), that associates with a variety of regulatory subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    deregulation playing a role in the pathogenesis of B-cell chronic lymphocytic leukaemia (Kalla 2007)
    tumoral     --other  
    aberrant transcripts of might be associated with the development of hepatocellular carcinoma (Chou 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS