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FLASH GENE
Symbol PPP1R16B contributors: mct - updated : 31-01-2011
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 16B
HGNC id 15850
Location 20q11.23      Physical location : 37.434.347 - 37.551.666
Synonym name
  • CAAX box protein TIMAP
  • TGF-beta-inhibited membrane-associated protein
  • ankyrin repeat domain protein 4
  • Synonym symbol(s) TIMAP, ANKRD4, KIAA0823
    DNA
    TYPE functioning gene
    STRUCTURE 117.32 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 6251 - 567 - 2002 12055102
    10 - 6145 - 525 - 2002 12055102
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   predominantly
     spleen   highly
     tonsils   predominantly
    Nervousbrain   lowly
    Reproductivemale systemtestis  highly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text lowly in brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • five ankyrin repeats
  • a protein phosphatase-1 (PP1)-interacting domain
  • a C-terminal CAAX box (where AA indicates aliphatic amino acid), a domain arrangement similar to that of MYPT3
  • a PP1 inhibitor
  • HOMOLOGY
    Homologene
    FAMILY
  • MYPT (myosin phosphatase target subunit) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text prenylated, endothelial cell-predominant protein phosphatase 1 (PP1c) regulatory subunit that localizes to the plasma membrane of filopodia
    basic FUNCTION
  • may serve a signaling function, potentially through interaction with PPYR1
  • may be involved in endothelial cytoskeletal and barrier regulation
  • involvement in PKA-mediated moesin dephosphorylation and this dephosphorylation is important in PPP1R16B-mediated endothelial cells barrier protection
  • regulatory subunit of myosin phosphatase in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPYR1
  • interacts with the 37/67 kDa laminin receptor (LAMR1), targets PPYR1 to LAMR1, and LAMR1 is a PPP1R16B-dependent PPYR1 substrate
  • interacting with cystein and glycine-rich protein 1, eukaryotic translation elongation factor 2, U5 snRNP-specific protein 116 kD
  • target for PKA-primed GSK3B-mediated phosphorylation
  • binds preferentially the beta-isoform of the catalytic subunit of PP1 (PP1CB) from pulmonary artery endothelial cells
  • cell & other
    REGULATION
    Other reglulated by TGF beta 1
    phosphorylation by GSK3B activates its associated protein phosphatase 1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS