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FLASH GENE
Symbol PPP1R16B contributors: mct - updated : 31-01-2011
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 16B
HGNC id 15850
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 6251 - 567 - 2002 12055102
10 - 6145 - 525 - 2002 12055102
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   predominantly
 spleen   highly
 tonsils   predominantly
Nervousbrain   lowly
Reproductivemale systemtestis  highly
Urinarykidney   lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text lowly in brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five ankyrin repeats
  • a protein phosphatase-1 (PP1)-interacting domain
  • a C-terminal CAAX box (where AA indicates aliphatic amino acid), a domain arrangement similar to that of MYPT3
  • a PP1 inhibitor
  • HOMOLOGY
    Homologene
    FAMILY
  • MYPT (myosin phosphatase target subunit) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text prenylated, endothelial cell-predominant protein phosphatase 1 (PP1c) regulatory subunit that localizes to the plasma membrane of filopodia
    basic FUNCTION
  • may serve a signaling function, potentially through interaction with PPYR1
  • may be involved in endothelial cytoskeletal and barrier regulation
  • involvement in PKA-mediated moesin dephosphorylation and this dephosphorylation is important in PPP1R16B-mediated endothelial cells barrier protection
  • regulatory subunit of myosin phosphatase in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPYR1
  • interacts with the 37/67 kDa laminin receptor (LAMR1), targets PPYR1 to LAMR1, and LAMR1 is a PPP1R16B-dependent PPYR1 substrate
  • interacting with cystein and glycine-rich protein 1, eukaryotic translation elongation factor 2, U5 snRNP-specific protein 116 kD
  • target for PKA-primed GSK3B-mediated phosphorylation
  • binds preferentially the beta-isoform of the catalytic subunit of PP1 (PP1CB) from pulmonary artery endothelial cells
  • cell & other
    REGULATION
    Other reglulated by TGF beta 1
    phosphorylation by GSK3B activates its associated protein phosphatase 1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS