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FLASH GENE
Symbol PPP1R15B contributors: mct - updated : 28-12-2015
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 15B
HGNC id 14951
Location 1q32.1      Physical location : 204.372.493 - 204.380.944
Synonym name
  • constitutive reverter of eIF2A phosphorylation (CReP)
    • Synonym symbol(s) FLJ14744, CREP
    DNA
    TYPE functioning gene
    STRUCTURE 8.45 kb     2 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 5284 79 713 - 2009 19181853
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • PPP1R15 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • inhibiting PP1
  • promoting dephosphorylation of the transcription initiation factor EIF2-alpha through recruitment of protein phosphatase 1 catalytic subunits (Harding 2009)
  • involved in EIF2A dephosphorylation, which is the predominant role of PPP1R15A and PPP1R15B in mammalian development
  • specific EIF2S1 phosphatases, PPP1R15A and PPP1R15B, play crucial roles in the recovery of protein synthesis following the initial insult
  • mammalian traffic machinery co-opts p-EIF2S1 and PPP1R15B regulators of translation initiation
  • role for PPP1R15B in the survival and therapy response of ESR1-positive breast cancer
  • preferentially translated PPP1R15A and constitutively expressed PPP1R15B function to dephosphorylate EIF2S1-Phosphorylated and restore protein synthesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of a complex containing PPP1R15B, PP1 and NCK1/2
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PPP1CA
  • novel role of PTEN in regulating stress response through modulating the PPP1R15B/EIF2S1 pathway
  • localized to membranes, and interacted with phosphomimetic EIF2S1
  • regulatory subunit of eukaryotic translation initiation factor 2alpha (EIF2S1) phosphatase, is a regulated ERN1-dependent decay (RIDD) substrate
  • BTRC substrate, and a Protein Phosphatase 1 (PP1) specificity subunit that targets the translation initiation factor EIF2S1 to promote the removal of a stress-induced inhibitory phosphorylation and increase cap-dependent translation
  • functions with the PPP1CA phosphatase to maintain dephosphorylated EIF2S1 in unstressed cells
  • preferentially translated PPP1R15A and constitutively expressed PPP1R15B function to dephosphorylate EIF2S1 and restore protein synthesis
  • coordinate regulation of UPR by the PPP1R15A- and PPP1R15B-containing EIF2S1 phosphatases to control cell viability
    • cell & other
    REGULATION
    inhibited by salubrinal, a drug that protects cells from E.R stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in microcephaly, short stature, hypoplastic brainstem and cord, delayed myelination and intellectual disability
    constitutional germinal mutation      
    in a novel syndrome of diabetes of youth with short stature, intellectual disability, and microcephaly
    constitutional     --low  
    depletion of PPP1R15B is required for the full induction of EIF2S1 phosphorylation upon DNA damage, and contributes to keeping the levels of translation low as cells recover from DNA damage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS