protein
| interacting with PPP1CA |
|
novel role of PTEN in regulating stress response through modulating the PPP1R15B/EIF2S1 pathway |
|
localized to membranes, and interacted with phosphomimetic EIF2S1 |
|
regulatory subunit of eukaryotic translation initiation factor 2alpha (EIF2S1) phosphatase, is a regulated ERN1-dependent decay (RIDD) substrate |
|
BTRC substrate, and a Protein Phosphatase 1 (PP1) specificity subunit that targets the translation initiation factor EIF2S1 to promote the removal of a stress-induced inhibitory phosphorylation and increase cap-dependent translation |
|
functions with the PPP1CA phosphatase to maintain dephosphorylated EIF2S1 in unstressed cells |
|
preferentially translated PPP1R15A and constitutively expressed PPP1R15B function to dephosphorylate EIF2S1 and restore protein synthesis |
|
coordinate regulation of UPR by the PPP1R15A- and PPP1R15B-containing EIF2S1 phosphatases to control cell viability |
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
| germinal mutation
|  
|  
|  
|
in microcephaly, short stature, hypoplastic brainstem and cord, delayed myelination and intellectual disability | constitutional
| germinal mutation
|  
|  
|  
|
in a novel syndrome of diabetes of youth with short stature, intellectual disability, and microcephaly | constitutional
|  
|  
| --low
|  
|
depletion of PPP1R15B is required for the full induction of EIF2S1 phosphorylation upon DNA damage, and contributes to keeping the levels of translation low as cells recover from DNA damage | |