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FLASH GENE

Symbol

PPAP2B

contributors: KTN/npt - updated : 13/10/2008

HGNC name	phosphatidic acid phosphatase type 2B
HGNC id	9229

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1pter-p22.1      Physical location : 56.960.432 - 57.045.257
Synonym name	vascular endothelial growth factor and type I collagen-inducible
	protein
	lipid phosphate phosphohydrolase 3
Synonym symbol(s)	PAP2B, LPP3, VCIP, Dri42, PAP2-b, PAP2-beta, MGC15306
EC.number	3.1.3.4

DNA

TYPE	functioning gene
STRUCTURE	84.83 kb     7 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 splicing 3310 35 311 - - containing an extra segment within the 5' UTR compared to variant 2 both variants encode the same protein variant 2 7 splicing 3243 35 311 - - lacking an internal segment within the 5' UTR compared to variant 1 both variants encode the same protein

EXPRESSION

Type	ubiquitous

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly   vessel       moderately Digestive pancreas exocrine       moderately Endocrine adrenal gland       moderately Nervous nerve       highly Reproductive female system placenta     predominantly   female system uterus     moderately Respiratory respiratory tract larynx     moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     moderately

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	predominantly in placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to dog PPAP2B (96.8 pc)
	homolog to cow PPAP2B (95.2 pc)
	homolog to rattus Ppap2b (94.9 pc)
	homolog to murine Ppap2b (94.9 pc)
	homolog to chicken PPAP2B (83.6 pc)

Homologene

FAMILY	PAP2 superfamily
	PA-phosphatase related phosphoesterase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	trans-Golgi network membrane
	multi-pass membrane protein
	type 2 plasma membrane-bound enzyme

basic FUNCTION	catalyzing the conversion of phosphatidic acid to diacylglycerol
	hydrolyzing lysophosphatidic acid, ceramide-1-phosphate and sphingosine-1-phosphate
	may be involved in cell adhesion and in cell-cell interactions
	involved in regulation of Wnt receptor signaling pathway

CELLULAR PROCESS

cell migration & motility

PHYSIOLOGICAL PROCESS

development

text	blood vessel development
	gastrulation with mouth forming second
	germ cell migration

PATHWAY

metabolism

lipid/lipoprotein

signaling

a component

complex confering only structural or functional stability

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

induced by	sphingosine, zinc ions and propanolol
		epidermal growth factor (EGF), vascular endothelial growrh factor (VEGF), basic fibroblast growth factor (bFGF) and phorbol myristate acetate (PMA)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function inactivated in renal clear cell carcinomas with poor prognosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS